Assay Detail
Binding
CHEMBL4705077
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Binding affinity to two PBDs of N36 trimer of gp41 in HIV1 NL4-3 infected in human TZM-bl cells assessed as inhibition of viral fusion incubated for 48 hrs by Steady-Glo luciferase assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | TZM-bl |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Bivalent HIV-1 fusion inhibitors based on peptidomimetics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.26 | 6.93 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 6.93 |
| CHEMBL440999 | — | — | 1 | 6.84 |
| CHEMBL2029368 | — | — | 1 | 5.80 |
| CHEMBL4790610 | — | — | 1 | 5.77 |
| CHEMBL4751670 | — | — | 1 | 4.99 |
| CHEMBL4751509 | — | — | 1 | 4.82 |
| CHEMBL4754444 | — | — | 1 | 4.77 |
| CHEMBL4762440 | — | — | 1 | 4.76 |
| CHEMBL4756365 | — | — | 1 | 4.69 |
| CHEMBL4780685 | — | — | 1 | 4.64 |
| CHEMBL4789822 | — | — | 1 | 4.62 |
| CHEMBL4764278 | — | — | 1 | 4.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | IC50 | = | 118.0 | nM | 6.93 |
| CHEMBL440999 | — | IC50 | = | 145.0 | nM | 6.84 |
| CHEMBL2029368 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL4790610 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL4751670 | — | IC50 | = | 10200.0 | nM | 4.99 |
| CHEMBL4751509 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL4754444 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL4762440 | — | IC50 | = | 17300.0 | nM | 4.76 |
| CHEMBL4756365 | — | IC50 | = | 20500.0 | nM | 4.69 |
| CHEMBL4780685 | — | IC50 | = | 22800.0 | nM | 4.64 |
| CHEMBL4789822 | — | IC50 | = | 23800.0 | nM | 4.62 |
| CHEMBL4764278 | — | IC50 | = | 36300.0 | nM | 4.44 |