Assay Detail
ADMET
CHEMBL4705387
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Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 24 hrs by Celltiter-blue assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Novel 2-Aniline-1,4-naphthoquinones as Potential New Drug Treatment for Leber's Hereditary Optic Neuropathy (LHON).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.36 | 4.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4755150 | — | — | 1 | 4.52 |
| CHEMBL252556 | IDEBENONE | 4.0 | 1 | 4.19 |
| CHEMBL4796280 | — | — | 1 | - |
| CHEMBL4744341 | — | — | 1 | - |
| CHEMBL4568469 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4755150 | — | IC50 | = | 30500.0 | nM | 4.52 |
| CHEMBL252556 | IDEBENONE | IC50 | = | 64500.0 | nM | 4.19 |
| CHEMBL4796280 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4744341 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4568469 | — | IC50 | > | 100000.0 | nM | - |