Assay Detail
Binding
CHEMBL4705469
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of N-terminal GST tagged wild-type human ALK cytoplasmic domain (1058-1620 amino acids) expressed Sf9 cells pre-incubated for 30 mins before addition of Ulight-CKKSRGDYMTMQIG substrate and measured after 90 mins by fluorescence based assay
42
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of CJ-2360 as a Potent and Orally Active Inhibitor of Anaplastic Lymphoma Kinase Capable of Achieving Complete Tumor Regression.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 42 | 8.30 | 9.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4790570 | — | — | 1 | 9.31 |
| CHEMBL1738797 | ALECTINIB | 4.0 | 1 | 9.23 |
| CHEMBL2403108 | CERITINIB | 4.0 | 1 | 9.21 |
| CHEMBL4799217 | — | — | 1 | 9.21 |
| CHEMBL4754012 | — | — | 1 | 9.00 |
| CHEMBL4761644 | — | — | 1 | 8.89 |
| CHEMBL4778565 | — | — | 1 | 8.89 |
| CHEMBL4778853 | — | — | 1 | 8.82 |
| CHEMBL4798441 | — | — | 1 | 8.80 |
| CHEMBL4764107 | — | — | 1 | 8.68 |
| CHEMBL4764610 | — | — | 1 | 8.66 |
| CHEMBL4747806 | — | — | 1 | 8.66 |
| CHEMBL4756825 | — | — | 1 | 8.60 |
| CHEMBL4787453 | — | — | 1 | 8.60 |
| CHEMBL4779307 | — | — | 1 | 8.59 |
| CHEMBL4747053 | — | — | 1 | 8.59 |
| CHEMBL4749002 | — | — | 1 | 8.43 |
| CHEMBL4745824 | — | — | 1 | 8.41 |
| CHEMBL4777376 | — | — | 1 | 8.40 |
| CHEMBL4755960 | — | — | 1 | 8.32 |
| CHEMBL4741360 | — | — | 1 | 8.32 |
| CHEMBL4797642 | — | — | 1 | 8.31 |
| CHEMBL4760756 | — | — | 1 | 8.28 |
| CHEMBL4788534 | — | — | 1 | 8.28 |
| CHEMBL4781855 | — | — | 1 | 8.27 |
| CHEMBL4776403 | — | — | 1 | 8.26 |
| CHEMBL4795124 | — | — | 1 | 8.24 |
| CHEMBL4795844 | — | — | 1 | 8.24 |
| CHEMBL4785020 | — | — | 1 | 8.18 |
| CHEMBL4753546 | — | — | 1 | 8.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4790570 | — | IC50 | = | 0.49 | nM | 9.31 |
| CHEMBL1738797 | ALECTINIB | IC50 | = | 0.59 | nM | 9.23 |
| CHEMBL4799217 | — | IC50 | = | 0.62 | nM | 9.21 |
| CHEMBL2403108 | CERITINIB | IC50 | = | 0.61 | nM | 9.21 |
| CHEMBL4754012 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4761644 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL4778565 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL4778853 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL4798441 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL4764107 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL4764610 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL4747806 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL4756825 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL4787453 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL4747053 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL4779307 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL4749002 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL4745824 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL4777376 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4755960 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL4741360 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL4797642 | — | IC50 | = | 4.9 | nM | 8.31 |
| CHEMBL4788534 | — | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL4760756 | — | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL4781855 | — | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL4776403 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL4795124 | — | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL4795844 | — | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL4785020 | — | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL4753546 | — | IC50 | = | 8.2 | nM | 8.09 |
| CHEMBL4781439 | — | IC50 | = | 8.9 | nM | 8.05 |
| CHEMBL4744052 | — | IC50 | = | 12.7 | nM | 7.90 |
| CHEMBL4780297 | — | IC50 | = | 13.5 | nM | 7.87 |
| CHEMBL4744640 | — | IC50 | = | 16.5 | nM | 7.78 |
| CHEMBL4787543 | — | IC50 | = | 19.8 | nM | 7.70 |
| CHEMBL4789803 | — | IC50 | = | 20.6 | nM | 7.69 |
| CHEMBL4741676 | — | IC50 | = | 21.3 | nM | 7.67 |
| CHEMBL4748562 | — | IC50 | = | 28.6 | nM | 7.54 |
| CHEMBL601719 | CRIZOTINIB | IC50 | = | 34.5 | nM | 7.46 |
| CHEMBL4796970 | — | IC50 | = | 40.5 | nM | 7.39 |
| CHEMBL4743395 | — | IC50 | = | 2503.0 | nM | 5.60 |
| CHEMBL4757803 | — | IC50 | > | 50000.0 | nM | - |