Assay Detail
Binding
CHEMBL4706278
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of beta lactamase TEM-1 in Enterobacter cloacae assessed as decrease in enzyme activity using nitrocefin as substrate preincubated for 10 mins followed by substrate addition measured for 10 mins by fluorescence plate reader analysis
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Enterobacter cloacae |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of ANT3310, a Novel Broad-Spectrum Serine β-Lactamase Inhibitor of the Diazabicyclooctane Class, Which Strongly Potentiates Meropenem Activity against Carbapenem-Resistant Enterobacterales and Acinetobacter baumannii.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 7.26 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4747858 | — | — | 1 | 9.00 |
| CHEMBL4747415 | — | — | 1 | 9.00 |
| CHEMBL4753698 | — | — | 1 | 9.00 |
| CHEMBL1689063 | AVIBACTAM | 4.0 | 1 | 8.30 |
| CHEMBL4760205 | — | — | 1 | 7.58 |
| CHEMBL4450418 | — | — | 1 | 7.17 |
| CHEMBL4751955 | — | — | 1 | 6.93 |
| CHEMBL4758199 | — | — | 1 | 6.87 |
| CHEMBL4783595 | — | — | 1 | 6.68 |
| CHEMBL4743152 | — | — | 1 | 6.67 |
| CHEMBL4784410 | — | — | 1 | 6.57 |
| CHEMBL4754954 | — | — | 1 | 6.39 |
| CHEMBL4762743 | — | — | 1 | 6.31 |
| CHEMBL4784710 | — | — | 1 | 6.29 |
| CHEMBL4753560 | — | — | 1 | 6.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4747858 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4747415 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4753698 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL1689063 | AVIBACTAM | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4760205 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL4450418 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL4751955 | — | IC50 | = | 117.0 | nM | 6.93 |
| CHEMBL4758199 | — | IC50 | = | 135.0 | nM | 6.87 |
| CHEMBL4783595 | — | IC50 | = | 208.0 | nM | 6.68 |
| CHEMBL4743152 | — | IC50 | = | 216.0 | nM | 6.67 |
| CHEMBL4784410 | — | IC50 | = | 267.0 | nM | 6.57 |
| CHEMBL4754954 | — | IC50 | = | 403.0 | nM | 6.39 |
| CHEMBL4762743 | — | IC50 | = | 492.0 | nM | 6.31 |
| CHEMBL4784710 | — | IC50 | = | 511.0 | nM | 6.29 |
| CHEMBL4753560 | — | IC50 | = | 810.0 | nM | 6.09 |