Assay Detail
Binding
CHEMBL4706334
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to C-terminal His6 tagged CAL PDZ domain (unknown origin) expressed in Escherichia coli BL21 incubated for 1 hr by fluorescence polarization based competition assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Golgi-associated PDZ and coiled-coil motif-containing protein (CHEMBL1741218) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Cyclic Peptidyl Inhibitors against CAL/CFTR Interaction for Treatment of Cystic Fibrosis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 7.39 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4756359 | — | — | 1 | 8.22 |
| CHEMBL4763464 | — | — | 1 | 7.31 |
| CHEMBL4789294 | — | — | 1 | 7.06 |
| CHEMBL4756115 | — | — | 1 | 6.95 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4756359 | — | Kd | = | 6.0 | nM | 8.22 |
| CHEMBL4763464 | — | Kd | = | 49.0 | nM | 7.31 |
| CHEMBL4789294 | — | Kd | = | 87.0 | nM | 7.06 |
| CHEMBL4756115 | — | Kd | = | 113.0 | nM | 6.95 |