Assay Detail
Binding
CHEMBL4706336
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to NHERF2 PDZ1 domain (unknown origin) expressed in Escherichia coli BL21 incubated for 1 hr by fluorescence polarization based competition assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (CHEMBL4739686) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Cyclic Peptidyl Inhibitors against CAL/CFTR Interaction for Treatment of Cystic Fibrosis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 5.77 | 6.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4763464 | — | — | 1 | 6.25 |
| CHEMBL4756359 | — | — | 1 | 5.86 |
| CHEMBL4756115 | — | — | 1 | 5.73 |
| CHEMBL4789294 | — | — | 1 | 5.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4763464 | — | Kd | = | 560.0 | nM | 6.25 |
| CHEMBL4756359 | — | Kd | = | 1370.0 | nM | 5.86 |
| CHEMBL4756115 | — | Kd | = | 1870.0 | nM | 5.73 |
| CHEMBL4789294 | — | Kd | = | 6040.0 | nM | 5.22 |