Assay Detail
Binding
CHEMBL4706441
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Binding affinity to PPAR-delta (unknown origin) by TR-FRET assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Peroxisome proliferator-activated receptor delta (CHEMBL3979) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery and Structure-Activity Relationships of Novel Template, Truncated 1'-Homologated Adenosine Derivatives as Pure Dual PPARγ/δ Modulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 6.89 | 8.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL592652 | — | — | 1 | 8.33 |
| CHEMBL38943 | GW501516 | 2.0 | 1 | 8.22 |
| CHEMBL413686 | — | — | 1 | 7.97 |
| CHEMBL1254751 | — | — | 1 | 6.97 |
| CHEMBL4758410 | — | — | 1 | 6.43 |
| CHEMBL4799672 | — | — | 1 | 6.30 |
| CHEMBL1254750 | — | — | 1 | 6.23 |
| CHEMBL4748172 | — | — | 1 | 5.84 |
| CHEMBL1254667 | — | — | 1 | 5.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL592652 | — | Ki | = | 4.65 | nM | 8.33 |
| CHEMBL38943 | GW501516 | Ki | = | 6.08 | nM | 8.22 |
| CHEMBL413686 | — | Ki | = | 10.6 | nM | 7.97 |
| CHEMBL1254751 | — | Ki | = | 106.0 | nM | 6.97 |
| CHEMBL4758410 | — | Ki | = | 374.0 | nM | 6.43 |
| CHEMBL4799672 | — | Ki | = | 504.0 | nM | 6.30 |
| CHEMBL1254750 | — | Ki | = | 592.0 | nM | 6.23 |
| CHEMBL4748172 | — | Ki | = | 1430.0 | nM | 5.84 |
| CHEMBL1254667 | — | Ki | = | 1910.0 | nM | 5.72 |