Assay Detail
Binding
CHEMBL4706451
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at PPARgamma LBD (unknown origin) assessed as increase in recruitment of coactivator peptide fluorescein-TRAP220/DRIP by TR-FRET assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Peroxisome proliferator-activated receptor gamma (CHEMBL235) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery and Structure-Activity Relationships of Novel Template, Truncated 1'-Homologated Adenosine Derivatives as Pure Dual PPARγ/δ Modulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 5.95 | 7.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL434063 | — | — | 1 | 7.77 |
| CHEMBL408 | TROGLITAZONE | 4.0 | 1 | 5.86 |
| CHEMBL1254751 | — | — | 1 | 5.16 |
| CHEMBL4758410 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL434063 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL408 | TROGLITAZONE | EC50 | = | 1380.0 | nM | 5.86 |
| CHEMBL1254751 | — | EC50 | = | 6850.0 | nM | 5.16 |
| CHEMBL4758410 | — | EC50 | = | 9950.0 | nM | 5.00 |