Assay Detail
Binding
CHEMBL4706780
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of N-terminal His6-tagged Plasmodium falciparum DHODH expressed in Escherichia coli BL21 using L-DHO as substrate and CoQ as co-substrate by DCIP dye based spectrophotometric assay
34
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Plasmodium falciparum |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Tetrahydro-2-naphthyl and 2-Indanyl Triazolopyrimidines Targeting Plasmodium falciparum Dihydroorotate Dehydrogenase Display Potent and Selective Antimalarial Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 7.01 | 8.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4761666 | — | — | 2 | 8.43 |
| CHEMBL4747214 | — | — | 2 | 8.34 |
| CHEMBL4753862 | — | — | 2 | 8.34 |
| CHEMBL4751920 | — | — | 1 | 8.20 |
| CHEMBL1956285 | DSM-265 | 2.0 | 1 | 8.05 |
| CHEMBL4790441 | — | — | 1 | 7.85 |
| CHEMBL4750037 | — | — | 2 | 7.82 |
| CHEMBL4751321 | — | — | 1 | 7.68 |
| CHEMBL4744317 | — | — | 2 | 7.68 |
| CHEMBL4740960 | — | — | 1 | 7.62 |
| CHEMBL4784152 | — | — | 1 | 7.32 |
| CHEMBL4740342 | — | — | 1 | 7.28 |
| CHEMBL4794107 | — | — | 1 | 7.28 |
| CHEMBL4760917 | — | — | 2 | 7.22 |
| CHEMBL4791257 | — | — | 1 | 7.19 |
| CHEMBL4760735 | — | — | 1 | 7.18 |
| CHEMBL4797521 | — | — | 1 | 7.11 |
| CHEMBL4784677 | — | — | 1 | 7.07 |
| CHEMBL4764319 | — | — | 1 | 7.06 |
| CHEMBL4777941 | — | — | 1 | 7.05 |
| CHEMBL4756700 | — | — | 1 | 6.96 |
| CHEMBL4797946 | — | — | 1 | 6.92 |
| CHEMBL4754938 | — | — | 1 | 6.85 |
| CHEMBL4741128 | — | — | 1 | 6.85 |
| CHEMBL3689094 | — | — | 1 | 6.77 |
| CHEMBL4764723 | — | — | 1 | 6.10 |
| CHEMBL4746414 | — | — | 1 | 5.40 |
| CHEMBL4748163 | — | — | 1 | 5.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4761666 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL4747214 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL4753862 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL4751920 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL1956285 | DSM-265 | IC50 | = | 8.9 | nM | 8.05 |
| CHEMBL4790441 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4750037 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4751321 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL4744317 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL4740960 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL4784152 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL4740342 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL4794107 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL4760917 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL4791257 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL4760735 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL4797521 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL4784677 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL4764319 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL4777941 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL4756700 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4797946 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL4754938 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4741128 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL3689094 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL4753862 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL4747214 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL4764723 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL4744317 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4750037 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4761666 | — | IC50 | = | 1340.0 | nM | 5.87 |
| CHEMBL4760917 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL4746414 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL4748163 | — | IC50 | = | 8000.0 | nM | 5.10 |