Assay Detail
Functional
CHEMBL4706783
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiplasmodial activity against Plasmodium falciparum 3D7 infected in RBC assessed as reduction in parasitemia incubated for 72 hrs by SYBR green dye-based assay
34
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Cell Type | RBC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Tetrahydro-2-naphthyl and 2-Indanyl Triazolopyrimidines Targeting Plasmodium falciparum Dihydroorotate Dehydrogenase Display Potent and Selective Antimalarial Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 34 | 7.29 | 9.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4753862 | — | — | 2 | 9.41 |
| CHEMBL4790441 | — | — | 1 | 9.41 |
| CHEMBL4751920 | — | — | 1 | 8.92 |
| CHEMBL4747214 | — | — | 2 | 8.59 |
| CHEMBL4751321 | — | — | 1 | 8.55 |
| CHEMBL4761666 | — | — | 2 | 8.42 |
| CHEMBL4760735 | — | — | 1 | 8.37 |
| CHEMBL1956285 | DSM-265 | 2.0 | 1 | 8.37 |
| CHEMBL4740960 | — | — | 1 | 8.12 |
| CHEMBL4741128 | — | — | 1 | 7.77 |
| CHEMBL3689094 | — | — | 1 | 7.68 |
| CHEMBL4760917 | — | — | 2 | 7.66 |
| CHEMBL4744317 | — | — | 2 | 7.60 |
| CHEMBL4750037 | — | — | 2 | 7.48 |
| CHEMBL4784152 | — | — | 1 | 7.44 |
| CHEMBL4794107 | — | — | 1 | 7.40 |
| CHEMBL4791257 | — | — | 1 | 7.34 |
| CHEMBL4740342 | — | — | 1 | 7.19 |
| CHEMBL4797521 | — | — | 1 | 7.18 |
| CHEMBL4777941 | — | — | 1 | 7.01 |
| CHEMBL4784677 | — | — | 1 | 6.92 |
| CHEMBL4797946 | — | — | 1 | 6.82 |
| CHEMBL4754938 | — | — | 1 | 6.24 |
| CHEMBL4756700 | — | — | 1 | 6.23 |
| CHEMBL4764723 | — | — | 1 | 5.55 |
| CHEMBL4764319 | — | — | 1 | 5.48 |
| CHEMBL4746414 | — | — | 1 | 5.19 |
| CHEMBL4748163 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4753862 | — | EC50 | = | 0.39 | nM | 9.41 |
| CHEMBL4790441 | — | EC50 | = | 0.39 | nM | 9.41 |
| CHEMBL4751920 | — | EC50 | = | 1.2 | nM | 8.92 |
| CHEMBL4747214 | — | EC50 | = | 2.6 | nM | 8.59 |
| CHEMBL4751321 | — | EC50 | = | 2.8 | nM | 8.55 |
| CHEMBL4761666 | — | EC50 | = | 3.8 | nM | 8.42 |
| CHEMBL1956285 | DSM-265 | EC50 | = | 4.3 | nM | 8.37 |
| CHEMBL4760735 | — | EC50 | = | 4.3 | nM | 8.37 |
| CHEMBL4740960 | — | EC50 | = | 7.5 | nM | 8.12 |
| CHEMBL4741128 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL3689094 | — | EC50 | = | 21.0 | nM | 7.68 |
| CHEMBL4760917 | — | EC50 | = | 22.0 | nM | 7.66 |
| CHEMBL4744317 | — | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL4750037 | — | EC50 | = | 33.0 | nM | 7.48 |
| CHEMBL4784152 | — | EC50 | = | 36.0 | nM | 7.44 |
| CHEMBL4794107 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL4791257 | — | EC50 | = | 46.0 | nM | 7.34 |
| CHEMBL4740342 | — | EC50 | = | 64.0 | nM | 7.19 |
| CHEMBL4797521 | — | EC50 | = | 66.0 | nM | 7.18 |
| CHEMBL4777941 | — | EC50 | = | 97.0 | nM | 7.01 |
| CHEMBL4784677 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL4747214 | — | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4797946 | — | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL4761666 | — | EC50 | = | 420.0 | nM | 6.38 |
| CHEMBL4754938 | — | EC50 | = | 580.0 | nM | 6.24 |
| CHEMBL4756700 | — | EC50 | = | 590.0 | nM | 6.23 |
| CHEMBL4744317 | — | EC50 | = | 640.0 | nM | 6.19 |
| CHEMBL4753862 | — | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL4750037 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL4764723 | — | EC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL4764319 | — | EC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL4746414 | — | EC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL4748163 | — | EC50 | - | — | - | |
| CHEMBL4760917 | — | EC50 | > | 2500.0 | nM | - |