Assay Detail
ADMET
CHEMBL4706802
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CYP2C8 in human liver microsomes using isoform-specific probe substrates in presence of NADPH-generating system by LC-MS analysis
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Tissue | Liver |
| Subcellular | Microsomes |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Tetrahydro-2-naphthyl and 2-Indanyl Triazolopyrimidines Targeting Plasmodium falciparum Dihydroorotate Dehydrogenase Display Potent and Selective Antimalarial Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.75 | 4.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4753862 | — | — | 1 | 4.77 |
| CHEMBL4747214 | — | — | 1 | 4.73 |
| CHEMBL4761666 | — | — | 1 | - |
| CHEMBL4751920 | — | — | 1 | - |
| CHEMBL4794107 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4753862 | — | IC50 | = | 16900.0 | nM | 4.77 |
| CHEMBL4747214 | — | IC50 | = | 18700.0 | nM | 4.73 |
| CHEMBL4761666 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4751920 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4794107 | — | IC50 | - | — | - |