Assay Detail
Functional
CHEMBL4707181
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human MV4-11 cells assessed as reduction in cell viability incubated for 72 hrs by sulforhodamine B assay/CellTiter-Glo luminescent assay
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MV4-11 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, Synthesis, and Preclinical Evaluation of Fused Pyrimidine-Based Hydroxamates for the Treatment of Hepatocellular Carcinoma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 36 | 6.39 | 7.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4798716 | — | — | 1 | 7.77 |
| CHEMBL4753381 | — | — | 1 | 7.52 |
| CHEMBL4787267 | — | — | 1 | 7.47 |
| CHEMBL4744689 | — | — | 1 | 7.36 |
| CHEMBL4785064 | — | — | 1 | 7.35 |
| CHEMBL4749655 | — | — | 1 | 7.33 |
| CHEMBL4742983 | — | — | 1 | 7.24 |
| CHEMBL4740827 | — | — | 1 | 7.23 |
| CHEMBL4799530 | — | — | 1 | 7.21 |
| CHEMBL4779376 | — | — | 1 | 7.21 |
| CHEMBL4780827 | — | — | 1 | 7.10 |
| CHEMBL4748726 | — | — | 1 | 6.89 |
| CHEMBL4796562 | — | — | 1 | 6.89 |
| CHEMBL4764799 | — | — | 1 | 6.77 |
| CHEMBL3393066 | VS-5584 | 1.0 | 1 | 6.70 |
| CHEMBL4744883 | — | — | 1 | 6.62 |
| CHEMBL4740074 | — | — | 1 | 6.60 |
| CHEMBL4776660 | — | — | 1 | 6.51 |
| CHEMBL4760754 | — | — | 1 | 6.42 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.37 |
| CHEMBL4752658 | — | — | 1 | 6.11 |
| CHEMBL4742243 | — | — | 1 | 5.87 |
| CHEMBL521851 | PICTILISIB | 2.0 | 1 | 5.84 |
| CHEMBL4787120 | — | — | 1 | 5.74 |
| CHEMBL4740916 | — | — | 1 | 5.73 |
| CHEMBL4746599 | — | — | 1 | 5.70 |
| CHEMBL4746214 | — | — | 1 | 5.62 |
| CHEMBL4758971 | — | — | 1 | 5.55 |
| CHEMBL4762615 | — | — | 1 | 5.26 |
| CHEMBL4786082 | — | — | 1 | 5.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4798716 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL4753381 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4787267 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL4744689 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL4785064 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL4749655 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL4742983 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL4740827 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL4799530 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL4779376 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL4780827 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL4748726 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4796562 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4764799 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL3393066 | VS-5584 | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4744883 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL4740074 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL4776660 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL4760754 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL4752658 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL4742243 | — | IC50 | = | 1360.0 | nM | 5.87 |
| CHEMBL521851 | PICTILISIB | IC50 | = | 1460.0 | nM | 5.84 |
| CHEMBL4787120 | — | IC50 | = | 1810.0 | nM | 5.74 |
| CHEMBL4740916 | — | IC50 | = | 1880.0 | nM | 5.73 |
| CHEMBL4746599 | — | IC50 | = | 1990.0 | nM | 5.70 |
| CHEMBL4746214 | — | IC50 | = | 2390.0 | nM | 5.62 |
| CHEMBL4758971 | — | IC50 | = | 2810.0 | nM | 5.55 |
| CHEMBL4762615 | — | IC50 | = | 5440.0 | nM | 5.26 |
| CHEMBL4786082 | — | IC50 | = | 5780.0 | nM | 5.24 |
| CHEMBL4799334 | — | IC50 | = | 6840.0 | nM | 5.17 |
| CHEMBL4789497 | — | IC50 | = | 7390.0 | nM | 5.13 |
| CHEMBL4760547 | — | IC50 | = | 9810.0 | nM | 5.01 |
| CHEMBL4744224 | — | IC50 | = | 20300.0 | nM | 4.69 |
| CHEMBL428496 | WORTMANNIN | IC50 | - | — | - | |
| CHEMBL1336 | SORAFENIB | IC50 | < | 6.0 | nM | - |