Assay Detail
Functional
CHEMBL4707182
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human PC-3 cells assessed as reduction in cell viability incubated for 72 hrs by sulforhodamine B assay/CellTiter-Glo luminescent assay
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PC-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, Synthesis, and Preclinical Evaluation of Fused Pyrimidine-Based Hydroxamates for the Treatment of Hepatocellular Carcinoma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 5.47 | 6.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3393066 | VS-5584 | 1.0 | 1 | 6.75 |
| CHEMBL521851 | PICTILISIB | 2.0 | 1 | 6.12 |
| CHEMBL4749655 | — | — | 1 | 5.97 |
| CHEMBL4744689 | — | — | 1 | 5.80 |
| CHEMBL4753381 | — | — | 1 | 5.78 |
| CHEMBL4748726 | — | — | 1 | 5.78 |
| CHEMBL4796562 | — | — | 1 | 5.77 |
| CHEMBL4744883 | — | — | 1 | 5.76 |
| CHEMBL4764799 | — | — | 1 | 5.71 |
| CHEMBL4760754 | — | — | 1 | 5.70 |
| CHEMBL4787267 | — | — | 1 | 5.65 |
| CHEMBL4740074 | — | — | 1 | 5.63 |
| CHEMBL4799530 | — | — | 1 | 5.56 |
| CHEMBL4776660 | — | — | 1 | 5.55 |
| CHEMBL4798716 | — | — | 1 | 5.52 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.51 |
| CHEMBL4740827 | — | — | 1 | 5.46 |
| CHEMBL4742983 | — | — | 1 | 5.45 |
| CHEMBL4780827 | — | — | 1 | 5.44 |
| CHEMBL4752658 | — | — | 1 | 5.44 |
| CHEMBL4785064 | — | — | 1 | 5.40 |
| CHEMBL4740916 | — | — | 1 | 5.33 |
| CHEMBL4787120 | — | — | 1 | 5.25 |
| CHEMBL4779376 | — | — | 1 | 5.22 |
| CHEMBL4746214 | — | — | 1 | 5.16 |
| CHEMBL4742243 | — | — | 1 | 5.12 |
| CHEMBL4746599 | — | — | 1 | 5.07 |
| CHEMBL4758971 | — | — | 1 | 5.03 |
| CHEMBL4789497 | — | — | 1 | 4.76 |
| CHEMBL4799334 | — | — | 1 | 4.76 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3393066 | VS-5584 | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL521851 | PICTILISIB | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL4749655 | — | IC50 | = | 1080.0 | nM | 5.97 |
| CHEMBL4744689 | — | IC50 | = | 1570.0 | nM | 5.80 |
| CHEMBL4753381 | — | IC50 | = | 1680.0 | nM | 5.78 |
| CHEMBL4748726 | — | IC50 | = | 1680.0 | nM | 5.78 |
| CHEMBL4796562 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL4744883 | — | IC50 | = | 1720.0 | nM | 5.76 |
| CHEMBL4764799 | — | IC50 | = | 1940.0 | nM | 5.71 |
| CHEMBL4760754 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL4787267 | — | IC50 | = | 2260.0 | nM | 5.65 |
| CHEMBL4740074 | — | IC50 | = | 2330.0 | nM | 5.63 |
| CHEMBL4799530 | — | IC50 | = | 2770.0 | nM | 5.56 |
| CHEMBL4776660 | — | IC50 | = | 2810.0 | nM | 5.55 |
| CHEMBL4798716 | — | IC50 | = | 3020.0 | nM | 5.52 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 3070.0 | nM | 5.51 |
| CHEMBL4740827 | — | IC50 | = | 3470.0 | nM | 5.46 |
| CHEMBL4742983 | — | IC50 | = | 3530.0 | nM | 5.45 |
| CHEMBL4752658 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL4780827 | — | IC50 | = | 3640.0 | nM | 5.44 |
| CHEMBL4785064 | — | IC50 | = | 4010.0 | nM | 5.40 |
| CHEMBL4740916 | — | IC50 | = | 4690.0 | nM | 5.33 |
| CHEMBL4787120 | — | IC50 | = | 5670.0 | nM | 5.25 |
| CHEMBL4779376 | — | IC50 | = | 6040.0 | nM | 5.22 |
| CHEMBL4746214 | — | IC50 | = | 6970.0 | nM | 5.16 |
| CHEMBL4742243 | — | IC50 | = | 7540.0 | nM | 5.12 |
| CHEMBL4746599 | — | IC50 | = | 8480.0 | nM | 5.07 |
| CHEMBL4758971 | — | IC50 | = | 9280.0 | nM | 5.03 |
| CHEMBL4789497 | — | IC50 | = | 17200.0 | nM | 4.76 |
| CHEMBL4799334 | — | IC50 | = | 17400.0 | nM | 4.76 |
| CHEMBL4760547 | — | IC50 | = | 18100.0 | nM | 4.74 |
| CHEMBL4786082 | — | IC50 | = | 18500.0 | nM | 4.73 |
| CHEMBL428496 | WORTMANNIN | IC50 | - | — | - | |
| CHEMBL4744224 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4762615 | — | IC50 | > | 25000.0 | nM | - |