Assay Detail
Functional
CHEMBL4707183
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Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 72 hrs by sulforhodamine B assay/CellTiter-Glo luminescent assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, Synthesis, and Preclinical Evaluation of Fused Pyrimidine-Based Hydroxamates for the Treatment of Hepatocellular Carcinoma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.75 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3393066 | VS-5584 | 1.0 | 1 | 6.89 |
| CHEMBL521851 | PICTILISIB | 2.0 | 1 | 6.66 |
| CHEMBL4787267 | — | — | 1 | 6.02 |
| CHEMBL4748726 | — | — | 1 | 5.92 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.80 |
| CHEMBL4740074 | — | — | 1 | 5.68 |
| CHEMBL4764799 | — | — | 1 | 5.59 |
| CHEMBL4758971 | — | — | 1 | 5.13 |
| CHEMBL4760547 | — | — | 1 | 4.96 |
| CHEMBL4744224 | — | — | 1 | 4.89 |
| CHEMBL428496 | WORTMANNIN | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3393066 | VS-5584 | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL521851 | PICTILISIB | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL4787267 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL4748726 | — | IC50 | = | 1210.0 | nM | 5.92 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL4740074 | — | IC50 | = | 2080.0 | nM | 5.68 |
| CHEMBL4764799 | — | IC50 | = | 2560.0 | nM | 5.59 |
| CHEMBL4758971 | — | IC50 | = | 7370.0 | nM | 5.13 |
| CHEMBL4760547 | — | IC50 | = | 11100.0 | nM | 4.96 |
| CHEMBL4744224 | — | IC50 | = | 12900.0 | nM | 4.89 |
| CHEMBL428496 | WORTMANNIN | IC50 | - | — | - |