Assay Detail
Binding
CHEMBL4707201
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human mTOR
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase mTOR (CHEMBL2842) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, Synthesis, and Preclinical Evaluation of Fused Pyrimidine-Based Hydroxamates for the Treatment of Hepatocellular Carcinoma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.39 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4744689 | — | — | 1 | 7.00 |
| CHEMBL573339 | PI-103 | — | 1 | 6.85 |
| CHEMBL4756541 | — | — | 1 | 6.82 |
| CHEMBL3622533 | FIMEPINOSTAT | 2.0 | 1 | 6.73 |
| CHEMBL4787267 | — | — | 1 | 6.54 |
| CHEMBL4760118 | — | — | 1 | 6.47 |
| CHEMBL4785064 | — | — | 1 | 6.43 |
| CHEMBL521851 | PICTILISIB | 2.0 | 1 | 6.02 |
| CHEMBL4749655 | — | — | 1 | 5.71 |
| CHEMBL4799530 | — | — | 1 | 5.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4744689 | — | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL573339 | PI-103 | IC50 | = | 141.0 | nM | 6.85 |
| CHEMBL4756541 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL3622533 | FIMEPINOSTAT | IC50 | = | 185.0 | nM | 6.73 |
| CHEMBL4787267 | — | IC50 | = | 288.0 | nM | 6.54 |
| CHEMBL4760118 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL4785064 | — | IC50 | = | 374.0 | nM | 6.43 |
| CHEMBL521851 | PICTILISIB | IC50 | = | 959.0 | nM | 6.02 |
| CHEMBL4749655 | — | IC50 | = | 1946.0 | nM | 5.71 |
| CHEMBL4799530 | — | IC50 | = | 4945.0 | nM | 5.31 |