Assay Detail
Binding
CHEMBL4707265
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HDAC6 in human MCF7 cells assessed as increase in acetylated alpha-tubulin at Lys40 residue incubated for 3 hrs by ELISA
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, Synthesis, and Preclinical Evaluation of Fused Pyrimidine-Based Hydroxamates for the Treatment of Hepatocellular Carcinoma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 6.58 | 6.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4749655 | — | — | 1 | 6.72 |
| CHEMBL4744689 | — | — | 1 | 6.66 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.37 |
| CHEMBL521851 | PICTILISIB | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4749655 | — | EC50 | = | 190.0 | nM | 6.72 |
| CHEMBL4744689 | — | EC50 | = | 220.0 | nM | 6.66 |
| CHEMBL98 | VORINOSTAT | EC50 | = | 430.0 | nM | 6.37 |
| CHEMBL521851 | PICTILISIB | EC50 | > | 30000.0 | nM | - |