Assay Detail
Functional
CHEMBL4707525
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Antagonist activity at CXCR4 in human CD4-positive T cells assessed as inhibition of CXCL12-induced calcium signal incubated for 20 mins by FLIPR assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CD4+ve Th |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structural optimization of aminopyrimidine-based CXCR4 antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 9.46 | 10.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4751485 | — | — | 1 | 10.70 |
| CHEMBL18442 | PLERIXAFOR | 4.0 | 1 | 8.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4751485 | — | IC50 | = | 0.02 | nM | 10.70 |
| CHEMBL18442 | PLERIXAFOR | IC50 | = | 6.134 | nM | 8.21 |