Assay Detail
Functional
CHEMBL4707713
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Antiproliferative activity against human G-361 cells assessed as cell viability measured after 4 days by MTT assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | G-361 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antitumor agents 7. Synthesis, antiproliferative activity and molecular modeling of new l-lysine-conjugated pyridophenoxazinones as potent DNA-binding ligands and topoisomerase IIα inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.43 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4744840 | — | — | 1 | 9.00 |
| CHEMBL4788620 | — | — | 1 | 8.22 |
| CHEMBL1554 | DACTINOMYCIN | 4.0 | 1 | 8.22 |
| CHEMBL151423 | — | — | 1 | 8.00 |
| CHEMBL4756108 | — | — | 1 | 7.70 |
| CHEMBL4780009 | — | — | 1 | 7.52 |
| CHEMBL4792590 | — | — | 1 | 7.30 |
| CHEMBL4740082 | — | — | 1 | 7.30 |
| CHEMBL4743363 | — | — | 1 | 7.22 |
| CHEMBL4786452 | — | — | 1 | 7.05 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.05 |
| CHEMBL346174 | — | — | 1 | 6.35 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 5.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4744840 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4788620 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL1554 | DACTINOMYCIN | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL151423 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4756108 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4780009 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4792590 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL4740082 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL4743363 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL4786452 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL346174 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 2300.0 | nM | 5.64 |