Assay Detail
Functional
CHEMBL4707904
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human MCF7 cells assessed as growth inhibition measured after 72 hrs by MTT assay
47
Total Activities
47
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and antineoplastic activity of novel 20(S)-acylthiourea derivatives of camptothecin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 47 | 6.48 | 7.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL84 | TOPOTECAN | 4.0 | 1 | 7.46 |
| CHEMBL4742027 | — | — | 1 | 7.38 |
| CHEMBL4794668 | — | — | 1 | 7.06 |
| CHEMBL4796705 | — | — | 1 | 7.00 |
| CHEMBL4777686 | — | — | 1 | 6.91 |
| CHEMBL4741887 | — | — | 1 | 6.86 |
| CHEMBL4754567 | — | — | 1 | 6.85 |
| CHEMBL4784440 | — | — | 1 | 6.84 |
| CHEMBL4794504 | — | — | 1 | 6.77 |
| CHEMBL4787367 | — | — | 1 | 6.75 |
| CHEMBL4764868 | — | — | 1 | 6.75 |
| CHEMBL4744610 | — | — | 1 | 6.70 |
| CHEMBL4754817 | — | — | 1 | 6.68 |
| CHEMBL4797363 | — | — | 1 | 6.66 |
| CHEMBL4786760 | — | — | 1 | 6.63 |
| CHEMBL4788934 | — | — | 1 | 6.59 |
| CHEMBL4764303 | — | — | 1 | 6.55 |
| CHEMBL4740751 | — | — | 1 | 6.50 |
| CHEMBL4789141 | — | — | 1 | 6.40 |
| CHEMBL4782938 | — | — | 1 | 6.40 |
| CHEMBL4750476 | — | — | 1 | 6.29 |
| CHEMBL4764642 | — | — | 1 | 6.28 |
| CHEMBL4787080 | — | — | 1 | 6.27 |
| CHEMBL4793468 | — | — | 1 | 6.23 |
| CHEMBL4761330 | — | — | 1 | 6.21 |
| CHEMBL4741735 | — | — | 1 | 6.21 |
| CHEMBL4779170 | — | — | 1 | 6.20 |
| CHEMBL4764604 | — | — | 1 | 6.15 |
| CHEMBL4783889 | — | — | 1 | 6.13 |
| CHEMBL4744197 | — | — | 1 | 6.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL84 | TOPOTECAN | IC50 | = | 34.5 | nM | 7.46 |
| CHEMBL4742027 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL4794668 | — | IC50 | = | 86.9 | nM | 7.06 |
| CHEMBL4796705 | — | IC50 | = | 98.9 | nM | 7.00 |
| CHEMBL4777686 | — | IC50 | = | 121.8 | nM | 6.91 |
| CHEMBL4741887 | — | IC50 | = | 136.8 | nM | 6.86 |
| CHEMBL4754567 | — | IC50 | = | 141.9 | nM | 6.85 |
| CHEMBL4784440 | — | IC50 | = | 142.9 | nM | 6.84 |
| CHEMBL4794504 | — | IC50 | = | 169.2 | nM | 6.77 |
| CHEMBL4787367 | — | IC50 | = | 179.5 | nM | 6.75 |
| CHEMBL4764868 | — | IC50 | = | 179.2 | nM | 6.75 |
| CHEMBL4744610 | — | IC50 | = | 198.0 | nM | 6.70 |
| CHEMBL4754817 | — | IC50 | = | 210.4 | nM | 6.68 |
| CHEMBL4797363 | — | IC50 | = | 218.1 | nM | 6.66 |
| CHEMBL4786760 | — | IC50 | = | 235.2 | nM | 6.63 |
| CHEMBL4788934 | — | IC50 | = | 258.8 | nM | 6.59 |
| CHEMBL4764303 | — | IC50 | = | 278.6 | nM | 6.55 |
| CHEMBL4740751 | — | IC50 | = | 318.9 | nM | 6.50 |
| CHEMBL4789141 | — | IC50 | = | 397.6 | nM | 6.40 |
| CHEMBL4782938 | — | IC50 | = | 400.8 | nM | 6.40 |
| CHEMBL4750476 | — | IC50 | = | 513.0 | nM | 6.29 |
| CHEMBL4764642 | — | IC50 | = | 520.2 | nM | 6.28 |
| CHEMBL4787080 | — | IC50 | = | 534.5 | nM | 6.27 |
| CHEMBL4793468 | — | IC50 | = | 583.8 | nM | 6.23 |
| CHEMBL4741735 | — | IC50 | = | 623.4 | nM | 6.21 |
| CHEMBL4761330 | — | IC50 | = | 618.7 | nM | 6.21 |
| CHEMBL4779170 | — | IC50 | = | 632.5 | nM | 6.20 |
| CHEMBL4764604 | — | IC50 | = | 703.0 | nM | 6.15 |
| CHEMBL4783889 | — | IC50 | = | 736.6 | nM | 6.13 |
| CHEMBL4744197 | — | IC50 | = | 762.5 | nM | 6.12 |
| CHEMBL4764591 | — | IC50 | = | 777.8 | nM | 6.11 |
| CHEMBL4758216 | — | IC50 | = | 801.9 | nM | 6.10 |
| CHEMBL4756330 | — | IC50 | = | 821.1 | nM | 6.09 |
| CHEMBL4752883 | — | IC50 | = | 814.4 | nM | 6.09 |
| CHEMBL4741783 | — | IC50 | = | 877.1 | nM | 6.06 |
| CHEMBL4780383 | — | IC50 | = | 897.7 | nM | 6.05 |
| CHEMBL4763180 | — | IC50 | = | 928.5 | nM | 6.03 |
| CHEMBL4756513 | — | IC50 | = | 943.8 | nM | 6.03 |
| CHEMBL4752958 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4742922 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4743143 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4780275 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4784813 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4788928 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4755881 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4785214 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4760371 | — | IC50 | > | 1000.0 | nM | - |