Assay Detail
Binding
CHEMBL4708026
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Inhibition of ALDH1A1 (unknown origin) assessed as NADH formation using propionaldehyde as substrate
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis characterization and biological evaluation of novel multi-isoform ALDH inhibitors as potential anticancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 6.10 | 6.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4793869 | — | — | 1 | 6.75 |
| CHEMBL4745360 | — | — | 1 | 6.64 |
| CHEMBL4755837 | — | — | 1 | 6.57 |
| CHEMBL4777582 | — | — | 1 | 6.55 |
| CHEMBL4754311 | — | — | 1 | 6.54 |
| CHEMBL4742685 | — | — | 1 | 6.48 |
| CHEMBL4755996 | — | — | 1 | 6.48 |
| CHEMBL4740863 | — | — | 1 | 6.44 |
| CHEMBL4752256 | — | — | 1 | 6.42 |
| CHEMBL4796029 | — | — | 1 | 6.40 |
| CHEMBL4764389 | — | — | 1 | 6.38 |
| CHEMBL4753971 | — | — | 1 | 6.22 |
| CHEMBL4763602 | — | — | 1 | 6.18 |
| CHEMBL4791741 | — | — | 1 | 5.98 |
| CHEMBL4787646 | — | — | 1 | 5.77 |
| CHEMBL4778505 | — | — | 1 | 5.33 |
| CHEMBL4793636 | — | — | 1 | 5.29 |
| CHEMBL4798414 | — | — | 1 | 5.28 |
| CHEMBL4781762 | — | — | 1 | 5.19 |
| CHEMBL4797385 | — | — | 1 | 5.07 |
| CHEMBL4779334 | — | — | 1 | - |
| CHEMBL4757065 | — | — | 1 | - |
| CHEMBL4782820 | — | — | 1 | - |
| CHEMBL4747569 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4793869 | — | IC50 | = | 177.0 | nM | 6.75 |
| CHEMBL4745360 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL4755837 | — | IC50 | = | 268.0 | nM | 6.57 |
| CHEMBL4777582 | — | IC50 | = | 279.0 | nM | 6.55 |
| CHEMBL4754311 | — | IC50 | = | 285.0 | nM | 6.54 |
| CHEMBL4742685 | — | IC50 | = | 334.0 | nM | 6.48 |
| CHEMBL4755996 | — | IC50 | = | 333.0 | nM | 6.48 |
| CHEMBL4740863 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL4752256 | — | IC50 | = | 384.0 | nM | 6.42 |
| CHEMBL4796029 | — | IC50 | = | 397.0 | nM | 6.40 |
| CHEMBL4764389 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL4753971 | — | IC50 | = | 598.0 | nM | 6.22 |
| CHEMBL4763602 | — | IC50 | = | 657.0 | nM | 6.18 |
| CHEMBL4791741 | — | IC50 | = | 1054.0 | nM | 5.98 |
| CHEMBL4787646 | — | IC50 | = | 1713.0 | nM | 5.77 |
| CHEMBL4778505 | — | IC50 | = | 4633.0 | nM | 5.33 |
| CHEMBL4793636 | — | IC50 | = | 5192.0 | nM | 5.29 |
| CHEMBL4798414 | — | IC50 | = | 5224.0 | nM | 5.28 |
| CHEMBL4781762 | — | IC50 | = | 6492.0 | nM | 5.19 |
| CHEMBL4797385 | — | IC50 | = | 8524.0 | nM | 5.07 |
| CHEMBL4779334 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4757065 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4782820 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4747569 | — | IC50 | > | 10000.0 | nM | - |