Assay Detail
Binding
CHEMBL4708169
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Inhibition of recombinant full length human HDAC6 expressed in SF9 baculovirus using FAM- labelled acetylated peptide as substrate measured by Electrophoretic mobility shift assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
PTG-0861: A novel HDAC6-selective inhibitor as a therapeutic strategy in acute myeloid leukaemia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 7.95 | 8.84 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4750701 | — | — | 1 | 8.84 |
| CHEMBL4757957 | — | — | 1 | 8.80 |
| CHEMBL4798826 | — | — | 1 | 8.70 |
| CHEMBL3693786 | CITARINOSTAT | 2.0 | 1 | 8.66 |
| CHEMBL2364628 | RICOLINOSTAT | 2.0 | 1 | 8.59 |
| CHEMBL4747455 | — | — | 1 | 8.55 |
| CHEMBL4784006 | — | — | 1 | 8.23 |
| CHEMBL4760306 | — | — | 1 | 8.17 |
| CHEMBL4742241 | — | — | 1 | 7.98 |
| CHEMBL4785378 | — | — | 1 | 7.92 |
| CHEMBL4755724 | — | — | 1 | 7.89 |
| CHEMBL4765007 | — | — | 1 | 7.85 |
| CHEMBL4763401 | — | — | 1 | 7.85 |
| CHEMBL4760053 | — | — | 1 | 7.76 |
| CHEMBL4744157 | — | — | 1 | 7.76 |
| CHEMBL4761127 | — | — | 1 | 7.74 |
| CHEMBL4755326 | — | — | 1 | 7.68 |
| CHEMBL4780745 | — | — | 1 | 7.65 |
| CHEMBL4452620 | — | — | 1 | 7.61 |
| CHEMBL4790223 | — | — | 1 | 7.58 |
| CHEMBL4799423 | — | — | 1 | 7.49 |
| CHEMBL4758855 | — | — | 1 | 7.38 |
| CHEMBL4638377 | — | — | 1 | 7.15 |
| CHEMBL4788731 | — | — | 1 | 7.01 |
| CHEMBL4792001 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4750701 | — | IC50 | = | 1.46 | nM | 8.84 |
| CHEMBL4757957 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL4798826 | — | IC50 | = | 2.01 | nM | 8.70 |
| CHEMBL3693786 | CITARINOSTAT | IC50 | = | 2.21 | nM | 8.66 |
| CHEMBL2364628 | RICOLINOSTAT | IC50 | = | 2.59 | nM | 8.59 |
| CHEMBL4747455 | — | IC50 | = | 2.81 | nM | 8.55 |
| CHEMBL4784006 | — | IC50 | = | 5.92 | nM | 8.23 |
| CHEMBL4760306 | — | IC50 | = | 6.77 | nM | 8.17 |
| CHEMBL4742241 | — | IC50 | = | 10.4 | nM | 7.98 |
| CHEMBL4785378 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4755724 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4765007 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4763401 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4760053 | — | IC50 | = | 17.5 | nM | 7.76 |
| CHEMBL4744157 | — | IC50 | = | 17.3 | nM | 7.76 |
| CHEMBL4761127 | — | IC50 | = | 18.4 | nM | 7.74 |
| CHEMBL4755326 | — | IC50 | = | 20.9 | nM | 7.68 |
| CHEMBL4780745 | — | IC50 | = | 22.6 | nM | 7.65 |
| CHEMBL4452620 | — | IC50 | = | 24.4 | nM | 7.61 |
| CHEMBL4790223 | — | IC50 | = | 26.6 | nM | 7.58 |
| CHEMBL4799423 | — | IC50 | = | 32.4 | nM | 7.49 |
| CHEMBL4758855 | — | IC50 | = | 41.9 | nM | 7.38 |
| CHEMBL4638377 | — | IC50 | = | 71.1 | nM | 7.15 |
| CHEMBL4788731 | — | IC50 | = | 96.6 | nM | 7.01 |
| CHEMBL4792001 | — | IC50 | > | 1000.0 | nM | - |