Assay Detail
Functional
CHEMBL4708339
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Cytotoxicity against human Hela assessed as reduction in cell viability measured after 72 hrs by MTT assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
F10, a new camptothecin derivative, was identified as a new orally-bioavailable, potent antitumor agent.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.30 | 6.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4795082 | — | — | 1 | 6.90 |
| CHEMBL837 | 7-ETHYL-10-HYDROXYCAMPTOTHECIN | 2.0 | 1 | 6.84 |
| CHEMBL4747562 | — | — | 1 | 6.46 |
| CHEMBL4752154 | — | — | 1 | 6.42 |
| CHEMBL4797512 | — | — | 1 | 6.00 |
| CHEMBL4744080 | — | — | 1 | 5.86 |
| CHEMBL4750133 | — | — | 1 | 5.59 |
| CHEMBL4785352 | — | — | 1 | - |
| CHEMBL4748272 | — | — | 1 | - |
| CHEMBL4753367 | — | — | 1 | - |
| CHEMBL4796475 | — | — | 1 | - |
| CHEMBL273862 | HYDROXYCAMPTOTHECIN | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4795082 | — | IC50 | = | 125.0 | nM | 6.90 |
| CHEMBL837 | 7-ETHYL-10-HYDROXYCAMPTOTHECIN | IC50 | = | 145.0 | nM | 6.84 |
| CHEMBL4747562 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL4752154 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL4797512 | — | IC50 | = | 1010.0 | nM | 6.00 |
| CHEMBL4744080 | — | IC50 | = | 1370.0 | nM | 5.86 |
| CHEMBL4750133 | — | IC50 | = | 2570.0 | nM | 5.59 |
| CHEMBL4785352 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4748272 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4753367 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4796475 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL273862 | HYDROXYCAMPTOTHECIN | IC50 | - | — | - |