Assay Detail
ADMET
CHEMBL4708487
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Cytotoxicity aganist human PBMC cells
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | PBMC |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Structure-based design, synthesis and bioactivity evaluation of macrocyclic inhibitors of mutant isocitrate dehydrogenase 2 (IDH2) displaying activity in acute myeloid leukemia cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.00 | 5.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4793173 | — | — | 1 | 5.00 |
| CHEMBL4784873 | — | — | 1 | 5.00 |
| CHEMBL4787510 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4793173 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4784873 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4787510 | — | IC50 | = | 10000.0 | nM | 5.00 |