Assay Detail
ADMET
CHEMBL4708702
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Cytotoxicity against CHO-K1 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Cricetulus griseus |
| Cell Type | CHO-K1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of novel berberine derivatives with balanced cholinesterase and prolyl oligopeptidase inhibition profile.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 4.51 | 5.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4747158 | — | — | 1 | 5.05 |
| CHEMBL4749346 | — | — | 1 | 4.89 |
| CHEMBL4747577 | — | — | 1 | 4.85 |
| CHEMBL4758271 | — | — | 1 | 4.77 |
| CHEMBL4752175 | — | — | 1 | 4.68 |
| CHEMBL4789099 | — | — | 1 | 4.64 |
| CHEMBL4745801 | — | — | 1 | 4.58 |
| CHEMBL4753534 | — | — | 1 | 4.52 |
| CHEMBL4759227 | — | — | 1 | 4.52 |
| CHEMBL4743436 | — | — | 1 | 4.50 |
| CHEMBL4762533 | — | — | 1 | 4.38 |
| CHEMBL4752813 | — | — | 1 | 4.38 |
| CHEMBL4790739 | — | — | 1 | 4.37 |
| CHEMBL4745802 | — | — | 1 | 4.37 |
| CHEMBL4762943 | — | — | 1 | 4.34 |
| CHEMBL4761840 | — | — | 1 | 4.32 |
| CHEMBL4748939 | — | — | 1 | 4.30 |
| CHEMBL4756491 | — | — | 1 | 4.26 |
| CHEMBL3621413 | — | — | 1 | 4.26 |
| CHEMBL4758460 | — | — | 1 | 4.24 |
| CHEMBL12089 | BERBERINE CHLORIDE | 1.0 | 1 | - |
| CHEMBL4745328 | — | — | 1 | - |
| CHEMBL4795843 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4747158 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL4749346 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL4747577 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL4758271 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL4752175 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL4789099 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL4745801 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL4753534 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL4759227 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL4743436 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL4762533 | — | IC50 | = | 42000.0 | nM | 4.38 |
| CHEMBL4752813 | — | IC50 | = | 42000.0 | nM | 4.38 |
| CHEMBL4790739 | — | IC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL4745802 | — | IC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL4762943 | — | IC50 | = | 46000.0 | nM | 4.34 |
| CHEMBL4761840 | — | IC50 | = | 48000.0 | nM | 4.32 |
| CHEMBL4748939 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL4756491 | — | IC50 | = | 55000.0 | nM | 4.26 |
| CHEMBL3621413 | — | IC50 | = | 55000.0 | nM | 4.26 |
| CHEMBL4758460 | — | IC50 | = | 58000.0 | nM | 4.24 |
| CHEMBL12089 | BERBERINE CHLORIDE | IC50 | = | 336000.0 | nM | - |
| CHEMBL4745328 | — | IC50 | - | — | - | |
| CHEMBL4795843 | — | IC50 | = | 292000.0 | nM | - |