Assay Detail
Functional
CHEMBL4709225
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Reversal of multidrug resistance activity in P-gp overexpressing human KB-VIN cells assessed as potentiation of VCR-induced cytotoxicity by measuring VCR IC50 at 10 uM incubated for 48 hrs in presence of VCR by MTT assay (Rvb = 666.3 nM)
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KB-VIN |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
New Seco-DSP derivatives as potent chemosensitizers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 8.75 | 8.98 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4743412 | — | — | 1 | 8.98 |
| CHEMBL4758059 | — | — | 1 | 8.97 |
| CHEMBL4755219 | — | — | 1 | 8.96 |
| CHEMBL4748813 | — | — | 1 | 8.94 |
| CHEMBL4779274 | — | — | 1 | 8.85 |
| CHEMBL4760012 | — | — | 1 | 8.80 |
| CHEMBL4795629 | — | — | 1 | 8.80 |
| CHEMBL6966 | VERAPAMIL | 4.0 | 1 | 8.80 |
| CHEMBL4793184 | — | — | 1 | 8.71 |
| CHEMBL4797081 | — | — | 1 | 8.71 |
| CHEMBL4777677 | — | — | 1 | 8.65 |
| CHEMBL4746188 | — | — | 1 | 8.57 |
| CHEMBL4743006 | — | — | 1 | 8.55 |
| CHEMBL4763859 | — | — | 1 | 8.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4743412 | — | IC50 | = | 1.053 | nM | 8.98 |
| CHEMBL4758059 | — | IC50 | = | 1.061 | nM | 8.97 |
| CHEMBL4755219 | — | IC50 | = | 1.103 | nM | 8.96 |
| CHEMBL4748813 | — | IC50 | = | 1.151 | nM | 8.94 |
| CHEMBL4779274 | — | IC50 | = | 1.429 | nM | 8.85 |
| CHEMBL4760012 | — | IC50 | = | 1.57 | nM | 8.80 |
| CHEMBL4795629 | — | IC50 | = | 1.588 | nM | 8.80 |
| CHEMBL6966 | VERAPAMIL | IC50 | = | 1.593 | nM | 8.80 |
| CHEMBL4793184 | — | IC50 | = | 1.942 | nM | 8.71 |
| CHEMBL4797081 | — | IC50 | = | 1.947 | nM | 8.71 |
| CHEMBL4777677 | — | IC50 | = | 2.228 | nM | 8.65 |
| CHEMBL4746188 | — | IC50 | = | 2.692 | nM | 8.57 |
| CHEMBL4743006 | — | IC50 | = | 2.842 | nM | 8.55 |
| CHEMBL4763859 | — | IC50 | = | 6.331 | nM | 8.20 |