Assay Detail
Binding
CHEMBL4709255
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human ERG by fluorescence polarization assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
An orally available inverse agonist of estrogen-related receptor gamma showed expanded efficacy for the radioiodine therapy of poorly differentiated thyroid cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.91 | 5.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4799011 | — | — | 1 | 5.37 |
| CHEMBL4741828 | — | — | 1 | 5.09 |
| CHEMBL4793030 | — | — | 1 | 4.99 |
| CHEMBL4746975 | — | — | 1 | 4.92 |
| CHEMBL4743534 | — | — | 1 | 4.90 |
| CHEMBL4746616 | — | — | 1 | 4.70 |
| CHEMBL4750724 | — | — | 1 | 4.66 |
| CHEMBL4597874 | — | — | 1 | 4.61 |
| CHEMBL4763285 | — | — | 1 | - |
| CHEMBL201013 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4799011 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL4741828 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL4793030 | — | IC50 | = | 10300.0 | nM | 4.99 |
| CHEMBL4746975 | — | IC50 | = | 11900.0 | nM | 4.92 |
| CHEMBL4743534 | — | IC50 | = | 12700.0 | nM | 4.90 |
| CHEMBL4746616 | — | IC50 | = | 20200.0 | nM | 4.70 |
| CHEMBL4750724 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL4597874 | — | IC50 | = | 24600.0 | nM | 4.61 |
| CHEMBL4763285 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL201013 | — | IC50 | > | 30000.0 | nM | - |