Assay Detail
Functional
CHEMBL4709424
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Antiproliferative activity against human COLO357 cells assessed as reduction in cell growth incubated for 72 hrs by MTT assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | COLO357 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of dihydrofuranoallocolchicinoids - Highly potent antimitotic agents with low acute toxicity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 7.35 | 10.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4794117 | — | — | 1 | 10.70 |
| CHEMBL4800456 | — | — | 1 | 10.40 |
| CHEMBL4753994 | — | — | 1 | 8.89 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 8.89 |
| CHEMBL4790387 | — | — | 1 | 8.30 |
| CHEMBL4800255 | — | — | 1 | 7.52 |
| CHEMBL4763296 | — | — | 1 | 6.82 |
| CHEMBL4749914 | — | — | 1 | 6.80 |
| CHEMBL4794755 | — | — | 1 | 6.80 |
| CHEMBL4755958 | — | — | 1 | 6.79 |
| CHEMBL4794828 | — | — | 1 | 6.10 |
| CHEMBL4748958 | — | — | 1 | 6.09 |
| CHEMBL4785493 | — | — | 1 | 6.08 |
| CHEMBL4755840 | — | — | 1 | 6.07 |
| CHEMBL4747128 | — | — | 1 | 6.06 |
| CHEMBL4749944 | — | — | 1 | 5.36 |
| CHEMBL4776448 | — | — | 1 | - |
| CHEMBL4750077 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4794117 | — | IC50 | = | 0.02 | nM | 10.70 |
| CHEMBL4800456 | — | IC50 | = | 0.04 | nM | 10.40 |
| CHEMBL4753994 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL107 | COLCHICINE | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL4790387 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4800255 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4763296 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL4749914 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL4794755 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL4755958 | — | IC50 | = | 161.0 | nM | 6.79 |
| CHEMBL4794828 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL4748958 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL4785493 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL4755840 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL4747128 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL4749944 | — | IC50 | = | 4330.0 | nM | 5.36 |
| CHEMBL4776448 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4750077 | — | IC50 | > | 4000.0 | nM | - |