Assay Detail
Functional
CHEMBL4709429
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Antiproliferative activity against human HeLa cells assessed as reduction in cell growth incubated for 72 hrs by MTT assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of dihydrofuranoallocolchicinoids - Highly potent antimitotic agents with low acute toxicity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.48 | 10.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4794117 | — | — | 1 | 10.52 |
| CHEMBL4753994 | — | — | 1 | 9.10 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 8.89 |
| CHEMBL4800456 | — | — | 1 | 8.77 |
| CHEMBL4790387 | — | — | 1 | 7.50 |
| CHEMBL4794828 | — | — | 1 | 6.82 |
| CHEMBL4755840 | — | — | 1 | 6.39 |
| CHEMBL4785493 | — | — | 1 | 6.09 |
| CHEMBL4776448 | — | — | 1 | 5.39 |
| CHEMBL4749944 | — | — | 1 | 5.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4794117 | — | IC50 | = | 0.03 | nM | 10.52 |
| CHEMBL4753994 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL107 | COLCHICINE | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL4800456 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL4790387 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL4794828 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL4755840 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL4785493 | — | IC50 | = | 805.0 | nM | 6.09 |
| CHEMBL4776448 | — | IC50 | = | 4025.0 | nM | 5.39 |
| CHEMBL4749944 | — | IC50 | = | 4250.0 | nM | 5.37 |