Assay Detail
Binding
CHEMBL4709792
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of IDO1 in IFN-gamma-induced human HeLa cells assessed as reduction in L-kynurenine formation using L-tryptophan as substrate incubated for 24 hrs
2
Total Activities
1
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery and structure-activity relationship studies of 1-aryl-1H-naphtho[2,3-d][1,2,3]triazole-4,9-dione derivatives as potent dual inhibitors of indoleamine 2,3-dioxygenase 1 (IDO1) and trytophan 2,3-dioxygenase (TDO).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Inhibition | 1 | - | - |
| IC50 | 1 | 7.01 | 7.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4787695 | — | — | 2 | 7.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4787695 | — | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL4787695 | — | Inhibition | - | % | - |