Assay Detail
Binding
CHEMBL4709937
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human MAO-B expressed in baculovirus infected BTI cells using p-tyramine as substrate by fluorometric assay
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | BTI |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Rational design of new multitarget histamine H receptor ligands as potential candidates for treatment of Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 6.09 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL396778 | SAFINAMIDE | 4.0 | 1 | 8.10 |
| CHEMBL887 | RASAGILINE | 4.0 | 1 | 7.60 |
| CHEMBL4744451 | — | — | 1 | 6.42 |
| CHEMBL4784081 | — | — | 1 | 6.18 |
| CHEMBL4786252 | — | — | 1 | 6.17 |
| CHEMBL4784501 | — | — | 1 | 6.14 |
| CHEMBL4790939 | — | — | 1 | 6.14 |
| CHEMBL4798732 | — | — | 1 | 6.12 |
| CHEMBL4797355 | — | — | 1 | 6.11 |
| CHEMBL4777210 | — | — | 1 | 6.07 |
| CHEMBL4783624 | — | — | 1 | 6.05 |
| CHEMBL4794003 | — | — | 1 | 6.03 |
| CHEMBL4797867 | — | — | 1 | 6.02 |
| CHEMBL4746282 | — | — | 1 | 6.01 |
| CHEMBL4747044 | — | — | 1 | 5.86 |
| CHEMBL4750579 | — | — | 1 | 5.82 |
| CHEMBL4796334 | — | — | 1 | 5.81 |
| CHEMBL4784025 | — | — | 1 | 5.81 |
| CHEMBL4741039 | — | — | 1 | 5.79 |
| CHEMBL4793206 | — | — | 1 | 5.74 |
| CHEMBL4785098 | — | — | 1 | 5.74 |
| CHEMBL4797681 | — | — | 1 | 5.73 |
| CHEMBL4757387 | — | — | 1 | 5.70 |
| CHEMBL4789324 | — | — | 1 | 5.68 |
| CHEMBL4759463 | — | — | 1 | 5.38 |
| CHEMBL95 | TACRINE | 4.0 | 1 | - |
| CHEMBL8706 | CLORGILINE | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL396778 | SAFINAMIDE | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL887 | RASAGILINE | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL4744451 | — | IC50 | = | 385.0 | nM | 6.42 |
| CHEMBL4784081 | — | IC50 | = | 665.0 | nM | 6.18 |
| CHEMBL4786252 | — | IC50 | = | 673.0 | nM | 6.17 |
| CHEMBL4784501 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL4790939 | — | IC50 | = | 717.0 | nM | 6.14 |
| CHEMBL4798732 | — | IC50 | = | 756.0 | nM | 6.12 |
| CHEMBL4797355 | — | IC50 | = | 775.0 | nM | 6.11 |
| CHEMBL4777210 | — | IC50 | = | 856.0 | nM | 6.07 |
| CHEMBL4783624 | — | IC50 | = | 897.0 | nM | 6.05 |
| CHEMBL4794003 | — | IC50 | = | 939.0 | nM | 6.03 |
| CHEMBL4797867 | — | IC50 | = | 946.0 | nM | 6.02 |
| CHEMBL4746282 | — | IC50 | = | 975.0 | nM | 6.01 |
| CHEMBL4747044 | — | IC50 | = | 1387.0 | nM | 5.86 |
| CHEMBL4750579 | — | IC50 | = | 1498.0 | nM | 5.82 |
| CHEMBL4796334 | — | IC50 | = | 1548.0 | nM | 5.81 |
| CHEMBL4784025 | — | IC50 | = | 1538.0 | nM | 5.81 |
| CHEMBL4741039 | — | IC50 | = | 1642.0 | nM | 5.79 |
| CHEMBL4793206 | — | IC50 | = | 1830.0 | nM | 5.74 |
| CHEMBL4785098 | — | IC50 | = | 1821.0 | nM | 5.74 |
| CHEMBL4797681 | — | IC50 | = | 1864.0 | nM | 5.73 |
| CHEMBL4757387 | — | IC50 | = | 1980.0 | nM | 5.70 |
| CHEMBL4789324 | — | IC50 | = | 2111.0 | nM | 5.68 |
| CHEMBL4759463 | — | IC50 | = | 4205.0 | nM | 5.38 |
| CHEMBL95 | TACRINE | IC50 | - | — | - | |
| CHEMBL8706 | CLORGILINE | IC50 | - | — | - |