Assay Detail

CHEMBL4710573

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Binding

Partial agonist activity at presynaptic D2 receptor (unknown origin)

ChEMBL ↗

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Target

D(2) dopamine receptor (CHEMBL217) ↗

Open DB target context

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D(2) dopamine receptor (CHEMBL217) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target D(2) dopamine receptor

CHEMBL217

Anchored from Assay target.

Protein identity D(2) dopamine receptor

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

D(2) dopamine receptor (CHEMBL217) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

New drug approvals for 2019: Synthesis and clinical applications.

Yuan S,Yu B,Liu HM
Eur J Med Chem (2020) 205 : 112667 -112667
PubMed 32911308 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	8.39	8.39

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL3306803	LUMATEPERONE	4.0	1	8.39

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL3306803	LUMATEPERONE	IC50	=	4.1	nM	8.39