Assay Detail
Binding
CHEMBL4710586
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Binding affinity to wild type TTR (unknown origin) expressed in Escherichia coli BL21/DE3 by Circular dichroism spectroscopy
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Transthyretin Amyloidogenesis Inhibitors: From Discovery to Current Developments.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 3 | 7.29 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL23588 | FLUFENAMIC ACID | 2.0 | 1 | 7.52 |
| CHEMBL139 | DICLOFENAC | 4.0 | 1 | 7.22 |
| CHEMBL898 | DIFLUNISAL | 4.0 | 1 | 7.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL23588 | FLUFENAMIC ACID | Kd | = | 30.0 | nM | 7.52 |
| CHEMBL139 | DICLOFENAC | Kd | = | 60.0 | nM | 7.22 |
| CHEMBL898 | DIFLUNISAL | Kd | = | 75.0 | nM | 7.12 |