Assay Detail
ADMET
CHEMBL4710606
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Phototoxicity against HUVEC assessed as reduction in cell viability preincubated for 4 hrs followed by irradiation with 0.3 W/cm2 of 625 +/- 2 nanometer LED light for 1 hr and measured after 42 hrs by MTT assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | HUVEC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Hydroxy-corrole and its gallium(III) complex as new photosensitizer for photodynamic therapy against breast carcinoma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.56 | 6.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4761734 | — | — | 1 | 6.05 |
| CHEMBL500576 | TEMOPORFIN | 4.0 | 1 | 5.82 |
| CHEMBL4757137 | — | — | 1 | 5.32 |
| CHEMBL4790123 | — | — | 1 | 5.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4761734 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL500576 | TEMOPORFIN | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL4757137 | — | IC50 | = | 4750.0 | nM | 5.32 |
| CHEMBL4790123 | — | IC50 | = | 9320.0 | nM | 5.03 |