Assay Detail
Binding
CHEMBL4710796
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Inhibition of beta-lactamase IMP-1 (unknown origin) expressed in Escherichia coli BL21(DE3) using imipenem as substrate by measuring substrate hydrolysis by spectrophotometric analysis
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Not specified |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
4-Amino-1,2,4-triazole-3-thione-derived Schiff bases as metallo-β-lactamase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 23 | 5.10 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4754134 | — | — | 1 | 7.00 |
| CHEMBL4796301 | — | — | 1 | 7.00 |
| CHEMBL4758987 | — | — | 1 | 6.52 |
| CHEMBL4751964 | — | — | 1 | 5.66 |
| CHEMBL4760501 | — | — | 1 | 5.52 |
| CHEMBL4780392 | — | — | 1 | 5.05 |
| CHEMBL4763927 | — | — | 1 | 5.05 |
| CHEMBL4758368 | — | — | 1 | 5.05 |
| CHEMBL4776119 | — | — | 1 | 5.05 |
| CHEMBL4778216 | — | — | 1 | 5.00 |
| CHEMBL4754312 | — | — | 1 | 4.97 |
| CHEMBL4785513 | — | — | 1 | 4.96 |
| CHEMBL4779391 | — | — | 1 | 4.96 |
| CHEMBL4789945 | — | — | 1 | 4.96 |
| CHEMBL4746528 | — | — | 1 | 4.94 |
| CHEMBL4757595 | — | — | 1 | 4.92 |
| CHEMBL4798128 | — | — | 1 | 4.75 |
| CHEMBL4760444 | — | — | 1 | 4.49 |
| CHEMBL4749729 | — | — | 1 | 4.46 |
| CHEMBL4792428 | — | — | 1 | 4.26 |
| CHEMBL4797119 | — | — | 1 | 4.24 |
| CHEMBL4790117 | — | — | 1 | 4.24 |
| CHEMBL4778397 | — | — | 1 | 4.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4754134 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL4796301 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL4758987 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL4751964 | — | Ki | = | 2200.0 | nM | 5.66 |
| CHEMBL4760501 | — | Ki | = | 3000.0 | nM | 5.52 |
| CHEMBL4780392 | — | Ki | = | 9000.0 | nM | 5.05 |
| CHEMBL4763927 | — | Ki | = | 9000.0 | nM | 5.05 |
| CHEMBL4758368 | — | Ki | = | 9000.0 | nM | 5.05 |
| CHEMBL4776119 | — | Ki | = | 9000.0 | nM | 5.05 |
| CHEMBL4778216 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL4754312 | — | Ki | = | 10600.0 | nM | 4.97 |
| CHEMBL4785513 | — | Ki | = | 11000.0 | nM | 4.96 |
| CHEMBL4779391 | — | Ki | = | 11000.0 | nM | 4.96 |
| CHEMBL4789945 | — | Ki | = | 11000.0 | nM | 4.96 |
| CHEMBL4746528 | — | Ki | = | 11400.0 | nM | 4.94 |
| CHEMBL4757595 | — | Ki | = | 12000.0 | nM | 4.92 |
| CHEMBL4798128 | — | Ki | = | 17700.0 | nM | 4.75 |
| CHEMBL4760444 | — | Ki | = | 32400.0 | nM | 4.49 |
| CHEMBL4749729 | — | Ki | = | 34400.0 | nM | 4.46 |
| CHEMBL4792428 | — | Ki | = | 54700.0 | nM | 4.26 |
| CHEMBL4797119 | — | Ki | = | 58000.0 | nM | 4.24 |
| CHEMBL4790117 | — | Ki | = | 58000.0 | nM | 4.24 |
| CHEMBL4778397 | — | Ki | = | 66200.0 | nM | 4.18 |