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Assay Detail

CHEMBL4710813

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of beta-lactamase VIM4 (unknown origin) expressed in Escherichia coli BL21(DE3) using imipenem as substrate by measuring substrate hydrolysis by spectrophotometric analysis
ChEMBL ↗
45
Total Activities
45
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Not specified
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545) ↗
Type UNCHECKED

Publication

4-Amino-1,2,4-triazole-3-thione-derived Schiff bases as metallo-β-lactamase inhibitors.
Gavara L,Sevaille L,De Luca F,Mercuri P,Bebrone C,Feller G,Legru A,Cerboni G,Tanfoni S,Baud D,Cutolo G,Bestgen B,Chelini G,Verdirosa F,Sannio F,Pozzi C,Benvenuti M,Kwapien K,Fischer M,Becker K,Frère JM,Mangani S,Gresh N,Berthomieu D,Galleni M,Docquier JD,Hernandez JF
Eur J Med Chem (2020) 208 : 112720 -112720
PubMed 32937203 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 45 5.75 7.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4798128 — — 1 7.40
CHEMBL4760501 — — 1 7.05
CHEMBL4788133 — — 1 6.70
CHEMBL4776119 — — 1 6.52
CHEMBL4754312 — — 1 6.40
CHEMBL4795172 — — 1 6.40
CHEMBL4799368 — — 1 6.30
CHEMBL4751855 — — 1 6.30
CHEMBL4754134 — — 1 6.22
CHEMBL4755906 — — 1 6.10
CHEMBL4783567 — — 1 6.00
CHEMBL4751263 — — 1 5.89
CHEMBL4745139 — — 1 5.85
CHEMBL4793498 — — 1 5.85
CHEMBL4764750 — — 1 5.85
CHEMBL4756626 — — 1 5.80
CHEMBL4790117 — — 1 5.80
CHEMBL4800663 — — 1 5.80
CHEMBL4782876 — — 1 5.77
CHEMBL4741466 — — 1 5.70
CHEMBL4780392 — — 1 5.70
CHEMBL4744599 — — 1 5.70
CHEMBL4740936 — — 1 5.70
CHEMBL4797119 — — 1 5.70
CHEMBL4758987 — — 1 5.68
CHEMBL4785513 — — 1 5.62
CHEMBL4796301 — — 1 5.62
CHEMBL4754823 — — 1 5.62
CHEMBL4794787 — — 1 5.55
CHEMBL4790053 — — 1 5.52

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4798128 — Ki = 40.0 nM 7.40
CHEMBL4760501 — Ki = 90.0 nM 7.05
CHEMBL4788133 — Ki = 200.0 nM 6.70
CHEMBL4776119 — Ki = 300.0 nM 6.52
CHEMBL4754312 — Ki = 400.0 nM 6.40
CHEMBL4795172 — Ki = 400.0 nM 6.40
CHEMBL4799368 — Ki = 500.0 nM 6.30
CHEMBL4751855 — Ki = 500.0 nM 6.30
CHEMBL4754134 — Ki = 600.0 nM 6.22
CHEMBL4755906 — Ki = 800.0 nM 6.10
CHEMBL4783567 — Ki = 1000.0 nM 6.00
CHEMBL4751263 — Ki = 1300.0 nM 5.89
CHEMBL4745139 — Ki = 1400.0 nM 5.85
CHEMBL4793498 — Ki = 1400.0 nM 5.85
CHEMBL4764750 — Ki = 1400.0 nM 5.85
CHEMBL4756626 — Ki = 1600.0 nM 5.80
CHEMBL4800663 — Ki = 1600.0 nM 5.80
CHEMBL4790117 — Ki = 1600.0 nM 5.80
CHEMBL4782876 — Ki = 1700.0 nM 5.77
CHEMBL4797119 — Ki = 2000.0 nM 5.70
CHEMBL4740936 — Ki = 2000.0 nM 5.70
CHEMBL4780392 — Ki = 2000.0 nM 5.70
CHEMBL4741466 — Ki = 2000.0 nM 5.70
CHEMBL4744599 — Ki = 2000.0 nM 5.70
CHEMBL4758987 — Ki = 2100.0 nM 5.68
CHEMBL4785513 — Ki = 2400.0 nM 5.62
CHEMBL4796301 — Ki = 2400.0 nM 5.62
CHEMBL4754823 — Ki = 2400.0 nM 5.62
CHEMBL4794787 — Ki = 2800.0 nM 5.55
CHEMBL4790053 — Ki = 3000.0 nM 5.52
CHEMBL4753438 — Ki = 3000.0 nM 5.52
CHEMBL4741184 — Ki = 3000.0 nM 5.52
CHEMBL4764187 — Ki = 3000.0 nM 5.52
CHEMBL4778397 — Ki = 3500.0 nM 5.46
CHEMBL4750169 — Ki = 4000.0 nM 5.40
CHEMBL4776223 — Ki = 4000.0 nM 5.40
CHEMBL4760444 — Ki = 4000.0 nM 5.40
CHEMBL4749729 — Ki = 5000.0 nM 5.30
CHEMBL4756300 — Ki = 5600.0 nM 5.25
CHEMBL4793107 — Ki = 6500.0 nM 5.19
CHEMBL4742890 — Ki = 7000.0 nM 5.16
CHEMBL4791345 — Ki = 9000.0 nM 5.05
CHEMBL4757595 — Ki = 9000.0 nM 5.05
CHEMBL4761193 — Ki = 13000.0 nM 4.89
CHEMBL4763735 — Ki = 20000.0 nM 4.70