Assay Detail
Binding
CHEMBL4711035
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-LSD from human 5HT6 receptor expressed in HEK293 cells measured after 1 hr by microbeta plate reader method
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A dual-acting 5-HT receptor inverse agonist/MAO-B inhibitor displays glioprotective and pro-cognitive properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 22 | 7.22 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL370779 | — | — | 1 | 9.52 |
| CHEMBL887 | RASAGILINE | 4.0 | 1 | 8.85 |
| CHEMBL4784859 | — | — | 1 | 8.15 |
| CHEMBL4741978 | — | — | 1 | 7.42 |
| CHEMBL4742220 | — | — | 1 | 7.30 |
| CHEMBL4780498 | — | — | 1 | 7.29 |
| CHEMBL4761469 | — | — | 1 | 7.27 |
| CHEMBL4754024 | — | — | 1 | 7.19 |
| CHEMBL4757296 | — | — | 1 | 7.17 |
| CHEMBL4780446 | — | — | 1 | 7.11 |
| CHEMBL4793457 | — | — | 1 | 7.00 |
| CHEMBL4794139 | — | — | 1 | 6.95 |
| CHEMBL4780366 | — | — | 1 | 6.86 |
| CHEMBL4778708 | — | — | 1 | 6.85 |
| CHEMBL4792096 | — | — | 1 | 6.80 |
| CHEMBL4777701 | — | — | 1 | 6.79 |
| CHEMBL4786924 | — | — | 1 | 6.71 |
| CHEMBL4754407 | — | — | 1 | 6.65 |
| CHEMBL4796358 | — | — | 1 | 6.63 |
| CHEMBL4745652 | — | — | 1 | 6.59 |
| CHEMBL4750021 | — | — | 1 | 6.47 |
| CHEMBL396778 | SAFINAMIDE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL370779 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL887 | RASAGILINE | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL4784859 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL4741978 | — | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL4742220 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL4780498 | — | Ki | = | 51.0 | nM | 7.29 |
| CHEMBL4761469 | — | Ki | = | 54.0 | nM | 7.27 |
| CHEMBL4754024 | — | Ki | = | 65.0 | nM | 7.19 |
| CHEMBL4757296 | — | Ki | = | 68.0 | nM | 7.17 |
| CHEMBL4780446 | — | Ki | = | 77.0 | nM | 7.11 |
| CHEMBL4793457 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL4794139 | — | Ki | = | 113.0 | nM | 6.95 |
| CHEMBL4780366 | — | Ki | = | 137.0 | nM | 6.86 |
| CHEMBL4778708 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL4792096 | — | Ki | = | 158.0 | nM | 6.80 |
| CHEMBL4777701 | — | Ki | = | 162.0 | nM | 6.79 |
| CHEMBL4786924 | — | Ki | = | 195.0 | nM | 6.71 |
| CHEMBL4754407 | — | Ki | = | 223.0 | nM | 6.65 |
| CHEMBL4796358 | — | Ki | = | 232.0 | nM | 6.63 |
| CHEMBL4745652 | — | Ki | = | 259.0 | nM | 6.59 |
| CHEMBL4750021 | — | Ki | = | 340.0 | nM | 6.47 |
| CHEMBL396778 | SAFINAMIDE | Ki | - | — | - |