Assay Detail
Binding
CHEMBL4711036
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Inhibition of recombinant human MAO-B expressed in baculovirus infected BTI insect cells using p-tyramine as substrate preincubated for 30 mins followed by substrate addition and measured after 1 hr by fluorimetric analysis
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | BTI |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A dual-acting 5-HT receptor inverse agonist/MAO-B inhibitor displays glioprotective and pro-cognitive properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 7.06 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL396778 | SAFINAMIDE | 4.0 | 1 | 8.15 |
| CHEMBL887 | RASAGILINE | 4.0 | 1 | 7.81 |
| CHEMBL4778708 | — | — | 1 | 7.52 |
| CHEMBL4741978 | — | — | 1 | 6.81 |
| CHEMBL4780498 | — | — | 1 | 6.79 |
| CHEMBL4794139 | — | — | 1 | 6.57 |
| CHEMBL4786924 | — | — | 1 | 6.49 |
| CHEMBL4754407 | — | — | 1 | 6.34 |
| CHEMBL4780446 | — | — | 1 | - |
| CHEMBL4745652 | — | — | 1 | - |
| CHEMBL4742220 | — | — | 1 | - |
| CHEMBL4792096 | — | — | 1 | - |
| CHEMBL4777701 | — | — | 1 | - |
| CHEMBL4796358 | — | — | 1 | - |
| CHEMBL4793457 | — | — | 1 | - |
| CHEMBL4757296 | — | — | 1 | - |
| CHEMBL4754024 | — | — | 1 | - |
| CHEMBL4780366 | — | — | 1 | - |
| CHEMBL4761469 | — | — | 1 | - |
| CHEMBL4750021 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL396778 | SAFINAMIDE | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL887 | RASAGILINE | IC50 | = | 15.4 | nM | 7.81 |
| CHEMBL4778708 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4741978 | — | IC50 | = | 154.0 | nM | 6.81 |
| CHEMBL4780498 | — | IC50 | = | 163.0 | nM | 6.79 |
| CHEMBL4794139 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL4786924 | — | IC50 | = | 323.0 | nM | 6.49 |
| CHEMBL4754407 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL4780446 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4745652 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4742220 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4792096 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4777701 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4796358 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4793457 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4757296 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4754024 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4780366 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4761469 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4750021 | — | IC50 | > | 1000.0 | nM | - |