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Assay Detail

CHEMBL4711039

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]-Ketanserin from human 5HT2A receptor expressed in CHOK1 cells incubated at 27 degree C for 1 hr by microbeta plate reader analysis
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type CHO-K1
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

5-hydroxytryptamine receptor 2A (CHEMBL224)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

A dual-acting 5-HT receptor inverse agonist/MAO-B inhibitor displays glioprotective and pro-cognitive properties.
Canale V,Grychowska K,Kurczab R,Ryng M,Keeri AR,Satała G,Olejarz-Maciej A,Koczurkiewicz P,Drop M,Blicharz K,Piska K,Pękala E,Janiszewska P,Krawczyk M,Walczak M,Chaumont-Dubel S,Bojarski AJ,Marin P,Popik P,Zajdel P
Eur J Med Chem (2020) 208 : 112765 -112765
PubMed 32949963 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1 6.38 6.38

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4741978 1 6.38

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4741978 Ki = 420.0 nM 6.38