Assay Detail
Binding
CHEMBL4711124
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of ULK1 (unknown origin) by 32P-ATP radio active assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase ULK1 (CHEMBL6006) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of 5-bromo-4-phenoxy-N-phenylpyrimidin-2-amine derivatives as novel ULK1 inhibitors that block autophagy and induce apoptosis in non-small cell lung cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.47 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3605055 | — | — | 1 | 8.10 |
| CHEMBL3605057 | — | — | 1 | 7.35 |
| CHEMBL4128069 | — | — | 1 | 6.97 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3605055 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL3605057 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL4128069 | — | IC50 | = | 108.0 | nM | 6.97 |