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Assay Detail

CHEMBL4711211

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Agonist activity at AhR in human HepG2 cells assessed as induction of AhR transcriptional activity incubated for 24 hrs by Quanti-Luc reagent based luminescence assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type HepG2
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Aryl hydrocarbon receptor (CHEMBL3201)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Targeting the aryl hydrocarbon receptor with a novel set of triarylmethanes.
Goya-Jorge E,Rampal C,Loones N,Barigye SJ,Carpio LE,Gozalbes R,Ferroud C,Sylla-Iyarreta Veitía M,Giner RM
Eur J Med Chem (2020) 207 : 112777 -112777
PubMed 32971427 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 1 5.04 5.04

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL472031 1 5.04

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL472031 EC50 = 9060.0 nM 5.04