Assay Detail
Functional
CHEMBL4711420
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Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
19
Total Activities
10
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of VEGFR-2 inhibitors exerting significant anticancer activity against CD44+ and CD133+ cancer stem cells (CSCs): Reversal of TGF-β induced epithelial-mesenchymal transition (EMT) in hepatocellular carcinoma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.00 | 6.02 |
| Inhibition | 9 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4753335 | — | — | 2 | 6.02 |
| CHEMBL4752531 | — | — | 2 | 6.02 |
| CHEMBL4742761 | — | — | 2 | 6.02 |
| CHEMBL4797532 | — | — | 2 | 6.02 |
| CHEMBL4799141 | — | — | 2 | 6.02 |
| CHEMBL4763007 | — | — | 2 | 6.02 |
| CHEMBL4785608 | — | — | 2 | 6.02 |
| CHEMBL4782839 | — | — | 2 | 6.02 |
| CHEMBL4745468 | — | — | 2 | 6.02 |
| CHEMBL1200485 | SORAFENIB TOSYLATE | 4.0 | 1 | 5.86 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4745468 | — | IC50 | = | 953.3 | nM | 6.02 |
| CHEMBL4782839 | — | IC50 | = | 953.3 | nM | 6.02 |
| CHEMBL4785608 | — | IC50 | = | 953.3 | nM | 6.02 |
| CHEMBL4763007 | — | IC50 | = | 953.3 | nM | 6.02 |
| CHEMBL4799141 | — | IC50 | = | 953.3 | nM | 6.02 |
| CHEMBL4797532 | — | IC50 | = | 953.3 | nM | 6.02 |
| CHEMBL4742761 | — | IC50 | = | 953.3 | nM | 6.02 |
| CHEMBL4753335 | — | IC50 | = | 953.3 | nM | 6.02 |
| CHEMBL4752531 | — | IC50 | = | 953.3 | nM | 6.02 |
| CHEMBL1200485 | SORAFENIB TOSYLATE | IC50 | = | 1384.0 | nM | 5.86 |
| CHEMBL4753335 | — | Inhibition | - | % | - | |
| CHEMBL4752531 | — | Inhibition | - | % | - | |
| CHEMBL4742761 | — | Inhibition | - | % | - | |
| CHEMBL4797532 | — | Inhibition | - | % | - | |
| CHEMBL4799141 | — | Inhibition | - | % | - | |
| CHEMBL4763007 | — | Inhibition | - | % | - | |
| CHEMBL4785608 | — | Inhibition | - | % | - | |
| CHEMBL4782839 | — | Inhibition | - | % | - | |
| CHEMBL4745468 | — | Inhibition | - | % | - |