Assay Detail
Binding
CHEMBL4711820
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human MAO-A expressed in baculovirus infected BTI-TN-5B1-4 insect cells using p-tyramine as substrate preincubated for 15 mins followed by substrate addition and measured over 20 mins by horse-radish peroxidase/Amplex Red coupled fluorimetric analysis
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | BTI-TN-5B1-4 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Pyrimido[1,2-b]indazole derivatives: Selective inhibitors of human monoamine oxidase B with neuroprotective activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 6.29 | 8.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL8706 | CLORGILINE | 2.0 | 1 | 8.47 |
| CHEMBL340807 | HARMALINE | — | 1 | 7.48 |
| CHEMBL4744827 | — | — | 1 | 4.68 |
| CHEMBL887 | RASAGILINE | 4.0 | 1 | 4.53 |
| CHEMBL396778 | SAFINAMIDE | 4.0 | 1 | - |
| CHEMBL4754874 | — | — | 1 | - |
| CHEMBL4783558 | — | — | 1 | - |
| CHEMBL4794759 | — | — | 1 | - |
| CHEMBL4795009 | — | — | 1 | - |
| CHEMBL4758739 | — | — | 1 | - |
| CHEMBL4779904 | — | — | 1 | - |
| CHEMBL4791844 | — | — | 1 | - |
| CHEMBL4759301 | — | — | 1 | - |
| CHEMBL4796620 | — | — | 1 | - |
| CHEMBL4748333 | — | — | 1 | - |
| CHEMBL4746018 | — | — | 1 | - |
| CHEMBL4783092 | — | — | 1 | - |
| CHEMBL4750291 | — | — | 1 | - |
| CHEMBL4753501 | — | — | 1 | - |
| CHEMBL4778686 | — | — | 1 | - |
| CHEMBL4785345 | — | — | 1 | - |
| CHEMBL4757484 | — | — | 1 | - |
| CHEMBL4748078 | — | — | 1 | - |
| CHEMBL4763130 | — | — | 1 | - |
| CHEMBL4798781 | — | — | 1 | - |
| CHEMBL4760176 | — | — | 1 | - |
| CHEMBL4752356 | — | — | 1 | - |
| CHEMBL4780349 | — | — | 1 | - |
| CHEMBL4753863 | — | — | 1 | - |
| CHEMBL4746352 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL8706 | CLORGILINE | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL340807 | HARMALINE | IC50 | = | 32.9 | nM | 7.48 |
| CHEMBL4744827 | — | IC50 | = | 21100.0 | nM | 4.68 |
| CHEMBL887 | RASAGILINE | IC50 | = | 29500.0 | nM | 4.53 |
| CHEMBL4794759 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4776405 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4795009 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4758739 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4779904 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4791844 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4759301 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4796620 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4748333 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4746018 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4783092 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4754874 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4746955 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4750851 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4749504 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4783558 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL396778 | SAFINAMIDE | IC50 | > | 10000.0 | nM | - |
| CHEMBL4750291 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4753501 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4778686 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4785345 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4757484 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4748078 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4763130 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4798781 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4760176 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4752356 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4780349 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4753863 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4746352 | — | IC50 | > | 100000.0 | nM | - |