Assay Detail
Functional
CHEMBL4712070
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Inhibition of HGF-induced cell scattering in human HPAF-II cells incubated for 1 hr by Hoechst staining based assay
3
Total Activities
2
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HPAF-II |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
From Pyrazolones to Azaindoles: Evolution of Active-Site SHP2 Inhibitors Based on Scaffold Hopping and Bioisosteric Replacement.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.53 | 5.58 |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4750435 | — | — | 2 | 5.58 |
| CHEMBL4762771 | — | — | 1 | 5.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4750435 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL4762771 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL4750435 | — | Inhibition | - | % | - |