Assay Detail
Functional
CHEMBL4712381
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Antiproliferative activity against human MCF7 cells incubated for 48 hrs by [3H]-thymidine incorporation assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Development of Potential Antitumor Agents from the Scaffolds of Plant-Derived Terpenoid Lactones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.16 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4750577 | — | — | 1 | 8.00 |
| CHEMBL404140 | OBACUNONE | — | 1 | 7.70 |
| CHEMBL4740267 | — | — | 1 | 7.01 |
| CHEMBL4788625 | — | — | 1 | 5.50 |
| CHEMBL517449 | LIMONIN | — | 1 | 5.37 |
| CHEMBL4747839 | — | — | 1 | 5.26 |
| CHEMBL4785234 | — | — | 1 | 4.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4750577 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL404140 | OBACUNONE | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4740267 | — | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL4788625 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL517449 | LIMONIN | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL4747839 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL4785234 | — | IC50 | = | 55000.0 | nM | 4.26 |