Assay Detail
Binding
CHEMBL4712397
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Inhibition of rat acid ceramidase
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, Synthesis, and Biological Evaluation of a Series of Oxazolone Carboxamides as a Novel Class of Acid Ceramidase Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.61 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2333033 | — | — | 1 | 7.92 |
| CHEMBL2333055 | — | — | 1 | 7.80 |
| CHEMBL460499 | CARMOFUR | 2.0 | 1 | 7.54 |
| CHEMBL2333032 | — | — | 1 | 7.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2333033 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL2333055 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL460499 | CARMOFUR | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL2333032 | — | IC50 | = | 67.0 | nM | 7.17 |