Assay Detail
Functional
CHEMBL4712495
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 72 hrs by CyQuant assay
47
Total Activities
47
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Novel Azetidine Amides as Potent Small-Molecule STAT3 Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 47 | 5.57 | 6.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4777016 | — | — | 1 | 6.05 |
| CHEMBL4754768 | — | — | 1 | 5.92 |
| CHEMBL4751592 | — | — | 1 | 5.85 |
| CHEMBL4776822 | — | — | 1 | 5.85 |
| CHEMBL4745657 | — | — | 1 | 5.80 |
| CHEMBL4780563 | — | — | 1 | 5.80 |
| CHEMBL4787896 | — | — | 1 | 5.77 |
| CHEMBL4753131 | — | — | 1 | 5.75 |
| CHEMBL4792177 | — | — | 1 | 5.75 |
| CHEMBL4762052 | — | — | 1 | 5.70 |
| CHEMBL4763364 | — | — | 1 | 5.70 |
| CHEMBL4758808 | — | — | 1 | 5.70 |
| CHEMBL4749034 | — | — | 1 | 5.70 |
| CHEMBL4782417 | — | — | 1 | 5.68 |
| CHEMBL4795749 | — | — | 1 | 5.68 |
| CHEMBL4753190 | — | — | 1 | 5.64 |
| CHEMBL4750471 | — | — | 1 | 5.64 |
| CHEMBL4749638 | — | — | 1 | 5.62 |
| CHEMBL4748816 | — | — | 1 | 5.57 |
| CHEMBL4756412 | — | — | 1 | 5.54 |
| CHEMBL4764216 | — | — | 1 | 5.51 |
| CHEMBL4764925 | — | — | 1 | 5.48 |
| CHEMBL4791146 | — | — | 1 | 5.40 |
| CHEMBL4746240 | — | — | 1 | 5.38 |
| CHEMBL4758309 | — | — | 1 | 5.36 |
| CHEMBL4744538 | — | — | 1 | 5.32 |
| CHEMBL4741333 | — | — | 1 | 5.30 |
| CHEMBL4780756 | — | — | 1 | 5.29 |
| CHEMBL4747080 | — | — | 1 | 5.29 |
| CHEMBL4741716 | — | — | 1 | 5.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4777016 | — | EC50 | = | 900.0 | nM | 6.05 |
| CHEMBL4754768 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4776822 | — | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL4751592 | — | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL4745657 | — | EC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL4780563 | — | EC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL4787896 | — | EC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL4753131 | — | EC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL4792177 | — | EC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL4762052 | — | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL4763364 | — | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL4758808 | — | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL4749034 | — | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL4782417 | — | EC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL4795749 | — | EC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL4753190 | — | EC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL4750471 | — | EC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL4749638 | — | EC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL4748816 | — | EC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL4756412 | — | EC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL4764216 | — | EC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL4764925 | — | EC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL4791146 | — | EC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL4746240 | — | EC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL4758309 | — | EC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL4744538 | — | EC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL4741333 | — | EC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL4780756 | — | EC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL4747080 | — | EC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL4741716 | — | EC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL4776532 | — | EC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL4782959 | — | EC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL4751709 | — | EC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL4794312 | — | EC50 | - | — | - | |
| CHEMBL4751026 | — | EC50 | - | — | - | |
| CHEMBL4757739 | — | EC50 | - | — | - | |
| CHEMBL4796258 | — | EC50 | - | — | - | |
| CHEMBL4778902 | — | EC50 | - | — | - | |
| CHEMBL4788811 | — | EC50 | - | — | - | |
| CHEMBL4789855 | — | EC50 | - | — | - | |
| CHEMBL4789779 | — | EC50 | - | — | - | |
| CHEMBL4742236 | — | EC50 | - | — | - | |
| CHEMBL4751861 | — | EC50 | - | — | - | |
| CHEMBL4760561 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4777307 | — | EC50 | - | — | - | |
| CHEMBL4761979 | — | EC50 | - | — | - | |
| CHEMBL4764228 | — | EC50 | - | — | - |