Assay Detail
Binding
CHEMBL4712543
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PI3K p110alpha H1047R mutant in human T47D cells assessed as reduction in phosphorylation of Akt at T308 residue incubated for 2 hrs by ELISA
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | T47D |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Structure-Based Drug Design and Synthesis of PI3Kα-Selective Inhibitor (PF-06843195).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.79 | 8.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4756555 | — | — | 1 | 8.06 |
| CHEMBL2396661 | ALPELISIB | 4.0 | 1 | 7.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4756555 | — | IC50 | = | 8.7 | nM | 8.06 |
| CHEMBL2396661 | ALPELISIB | IC50 | = | 30.0 | nM | 7.52 |