Assay Detail
Functional
CHEMBL4712760
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Antileishmanial activity against Leishmania infantum infected in mouse primary macrophages
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Leishmania infantum |
| Cell Type | Primary macrophage |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of a collection of purine-like C-nucleosides as antikinetoplastid agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 5.04 | 5.95 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4744476 | — | — | 1 | 5.95 |
| CHEMBL4742019 | — | — | 1 | 5.50 |
| CHEMBL4788848 | — | — | 1 | 5.29 |
| CHEMBL4777562 | — | — | 1 | 5.25 |
| CHEMBL125 | MILTEFOSINE | 4.0 | 1 | 5.13 |
| CHEMBL4758694 | — | — | 1 | 4.66 |
| CHEMBL4764464 | — | — | 1 | 4.63 |
| CHEMBL4755821 | — | — | 1 | 4.49 |
| CHEMBL4794928 | — | — | 1 | 4.47 |
| CHEMBL4751562 | — | — | 1 | - |
| CHEMBL4787773 | — | — | 1 | - |
| CHEMBL4079082 | — | — | 1 | - |
| CHEMBL4634483 | — | — | 1 | - |
| CHEMBL4764594 | — | — | 1 | - |
| CHEMBL4758898 | — | — | 1 | - |
| CHEMBL4790411 | — | — | 1 | - |
| CHEMBL2016757 | GS-441524 | 1.0 | 1 | - |
| CHEMBL4753867 | — | — | 1 | - |
| CHEMBL4751346 | — | — | 1 | - |
| CHEMBL4793136 | — | — | 1 | - |
| CHEMBL4783188 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4744476 | — | IC50 | = | 1130.0 | nM | 5.95 |
| CHEMBL4742019 | — | IC50 | = | 3170.0 | nM | 5.50 |
| CHEMBL4788848 | — | IC50 | = | 5150.0 | nM | 5.29 |
| CHEMBL4777562 | — | IC50 | = | 5660.0 | nM | 5.25 |
| CHEMBL125 | MILTEFOSINE | IC50 | = | 7470.0 | nM | 5.13 |
| CHEMBL4758694 | — | IC50 | = | 21900.0 | nM | 4.66 |
| CHEMBL4764464 | — | IC50 | = | 23300.0 | nM | 4.63 |
| CHEMBL4755821 | — | IC50 | = | 32500.0 | nM | 4.49 |
| CHEMBL4794928 | — | IC50 | = | 34200.0 | nM | 4.47 |
| CHEMBL4751562 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL4787773 | — | IC50 | >= | 50800.0 | nM | - |
| CHEMBL4079082 | — | IC50 | < | 250.0 | nM | - |
| CHEMBL4634483 | — | IC50 | = | 236000.0 | nM | - |
| CHEMBL4764594 | — | IC50 | >= | 40300.0 | nM | - |
| CHEMBL4758898 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL4790411 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL2016757 | GS-441524 | IC50 | > | 64000.0 | nM | - |
| CHEMBL4753867 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL4751346 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL4793136 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL4783188 | — | IC50 | > | 64000.0 | nM | - |