Assay Detail
Binding
CHEMBL4713207
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of FITC-GDA binding to human HSP90-alpha incubated for 2 hrs by fluorescence polarization assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
The Development of Hsp90β-Selective Inhibitors to Overcome Detriments Associated with pan-Hsp90 Inhibition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 6.27 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3235353 | — | — | 1 | 8.30 |
| CHEMBL560895 | SNX-2112 | -1.0 | 1 | 8.22 |
| CHEMBL4756421 | — | — | 1 | 6.76 |
| CHEMBL4474770 | — | — | 1 | 6.75 |
| CHEMBL4740273 | — | — | 1 | 6.75 |
| CHEMBL4763549 | — | — | 1 | 6.53 |
| CHEMBL4791530 | — | — | 1 | 6.51 |
| CHEMBL4763239 | — | — | 1 | 6.08 |
| CHEMBL4796520 | — | — | 1 | 6.05 |
| CHEMBL4740377 | — | — | 1 | 5.80 |
| CHEMBL4796556 | — | — | 1 | 5.73 |
| CHEMBL4786075 | — | — | 1 | 5.07 |
| CHEMBL4756340 | — | — | 1 | 4.77 |
| CHEMBL4787078 | — | — | 1 | 4.42 |
| CHEMBL4761885 | — | — | 1 | - |
| CHEMBL4789323 | — | — | 1 | - |
| CHEMBL4791941 | — | — | 1 | - |
| CHEMBL4762355 | — | — | 1 | - |
| CHEMBL4739925 | — | — | 1 | - |
| CHEMBL4781194 | — | — | 1 | - |
| CHEMBL4744768 | — | — | 1 | - |
| CHEMBL4761498 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3235353 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL560895 | SNX-2112 | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4756421 | — | IC50 | = | 173.0 | nM | 6.76 |
| CHEMBL4474770 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL4740273 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL4763549 | — | IC50 | = | 294.0 | nM | 6.53 |
| CHEMBL4791530 | — | IC50 | = | 306.0 | nM | 6.51 |
| CHEMBL4763239 | — | IC50 | = | 824.0 | nM | 6.08 |
| CHEMBL4796520 | — | IC50 | = | 886.0 | nM | 6.05 |
| CHEMBL4740377 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL4796556 | — | IC50 | = | 1880.0 | nM | 5.73 |
| CHEMBL4786075 | — | IC50 | = | 8520.0 | nM | 5.07 |
| CHEMBL4756340 | — | IC50 | = | 17083.0 | nM | 4.77 |
| CHEMBL4787078 | — | IC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL4761885 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4789323 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4791941 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4762355 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4739925 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4781194 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4744768 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4761498 | — | IC50 | > | 50000.0 | nM | - |