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Assay Detail

CHEMBL4713836

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of PGAM1 (unknown origin)
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Phosphoglycerate mutase 1 (CHEMBL3334418)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Design, synthesis, and biological evaluation of 1,3,6,7-tetrahydroxyxanthone derivatives as phosphoglycerate mutase 1 inhibitors.
Jiang K,Gao B,Yu J,Jiang L,Niu A,Jia Y,Meng T,Zhou L,Wang J
Bioorg Med Chem Lett (2021) 36 : 127820 -127820
PubMed 33513389 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 21 5.46 6.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL186784 XANTHONE 1 6.30
CHEMBL4776823 1 5.82
CHEMBL260553 1 5.72
CHEMBL175336 Alizarin Red S 1 5.64
CHEMBL4775985 1 5.55
CHEMBL4748271 1 5.55
CHEMBL519864 1 5.47
CHEMBL4796535 1 5.24
CHEMBL323197 MANGOSTIN 1 5.14
CHEMBL4783891 1 4.89
CHEMBL4795940 1 4.70
CHEMBL4780214 1 -
CHEMBL4753391 1 -
CHEMBL4764008 1 -
CHEMBL4781391 1 -
CHEMBL3335789 1 -
CHEMBL4798860 1 -
CHEMBL4764347 1 -
CHEMBL4743146 1 -
CHEMBL4760327 1 -
CHEMBL4755313 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL186784 XANTHONE IC50 = 500.0 nM 6.30
CHEMBL4776823 IC50 = 1500.0 nM 5.82
CHEMBL260553 IC50 = 1900.0 nM 5.72
CHEMBL175336 Alizarin Red S IC50 = 2300.0 nM 5.64
CHEMBL4775985 IC50 = 2800.0 nM 5.55
CHEMBL4748271 IC50 = 2800.0 nM 5.55
CHEMBL519864 IC50 = 3400.0 nM 5.47
CHEMBL4796535 IC50 = 5700.0 nM 5.24
CHEMBL323197 MANGOSTIN IC50 = 7200.0 nM 5.14
CHEMBL4783891 IC50 = 12800.0 nM 4.89
CHEMBL4795940 IC50 = 20000.0 nM 4.70
CHEMBL4780214 IC50 > 20000.0 nM -
CHEMBL4753391 IC50 > 20000.0 nM -
CHEMBL4764008 IC50 > 20000.0 nM -
CHEMBL4781391 IC50 > 20000.0 nM -
CHEMBL3335789 IC50 > 20000.0 nM -
CHEMBL4798860 IC50 > 20000.0 nM -
CHEMBL4764347 IC50 > 20000.0 nM -
CHEMBL4743146 IC50 > 20000.0 nM -
CHEMBL4760327 IC50 > 20000.0 nM -
CHEMBL4755313 IC50 > 20000.0 nM -